e-Drug3D

1878

AVATROMBOPAG

INN
AVATROMBOPAG

cas 570406-98-3

CLASS

BLOOD
THROMBOPOIETIN RECEPTOR AGONIST (TPO)
TREATMENT OF THROMBOCYTOPENIA
INCREASED PRODUCTION OF PLATELETS

ROUTE (list)

ORAL

ATC code

B02BX08

PK parameters

Tmax 5.5 HOUR
Cmax 255.6 NANOMOLAR
VD 180 LITER
Cl 6.9 LITER / HOUR
PPB 96 PERCENT
t1/2 19 HOUR

Solubility

PRACTICALLY INSOLUBLE AT PH 1 TO 11

Target

TARGET THROMBOPOIETIN RECEPTOR

DrugCentral

Thrombopoietin receptor UNIPROT P40238 MPL

Download SDF file

4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-

Formula:
C29H34Cl2N6O3S2

Calculated chemical properties:

MW 648.65
NB_atoms 42
XLogP 5.25
PSA 94.885
NB_HD 1
NB_HA 9
fsp3 0.52
Lipinski(0=no;1=yes) 0

FDA
NDA 210238 (label) INN (AVATROMBOPAG MALEATE) DOPTELET (AKARX INC) APPROVAL= AP YEAR= 2018
NDA 219696 (label) INN (AVATROMBOPAG MALEATE) DOPTELET SPRINKLE (AKARX INC) APPROVAL= AP YEAR= 2025