e-Drug3D

1799

cas 357336-20-0

CLASS

NERVOUS SYSTEM
TREATMENT OF PARTIAL-ONSET SEIZURES
ANTIEPILEPTIC
HIGH AND SELECTIVE AFFINITY FOR SYNAPTIC VESICLE PROTEIN 2A (SV2A) IN THE BRAIN

ROUTE (list)

ORAL INTRAVENOUS

PK parameters

Tmax 1 HOUR
VD 32.5 LITER (65 KILOGRAM)
PPB 20 PERCENT
t1/2 9 HOUR

TARGET SYNAPTIC VESICLE GLYCOPROTEIN 2A (SV2A)

PDB
8K77 (CRYO-EM STRUCTURE OF SV2A IN COMPLEX WITH BONT, A2 HC AND BRIVARACETAM)

Ligand code = VLX (link to the list of PDB complexes)

Download experimental 3D coordinates of VLX with added hydrogens

MW 212.29
NB_atoms 15
XLogP 0.90
PSA 56.951
NB_HD 2
NB_HA 4
fsp3 0.82
Lipinski(0=no;1=yes) 1

FDA
NDA 205836 (label) INN (BRIVARACETAM) BRIVIACT (UCB INC) APPROVAL= AP YEAR= 2016
NDA 205837 (label) INN (BRIVARACETAM) BRIVIACT (UCB INC) APPROVAL= AP YEAR= 2016
NDA 205838 (label) INN (BRIVARACETAM) BRIVIACT (UCB INC) APPROVAL= AP YEAR= 2016
NDA 214501 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (ZYDUS PHARMS) APPROVAL= AP YEAR= 2022
NDA 214918 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (LUPIN) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 214748 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (SUNSHINE) APPROVAL= AP YEAR= 2022
NDA 214848 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2023
NDA 214831 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (ANNORA PHARMA) APPROVAL= TA YEAR= 2024
NDA 214921 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (MSN) APPROVAL= AP YEAR= 2025
NDA 214924 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (MSN) APPROVAL= AP YEAR= 2026
NDA 214875 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (APOTEX) APPROVAL= AP YEAR= 2026
NDA 214922 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (MSN) APPROVAL= AP YEAR= 2026
NDA 218494 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (ZHEJIANG POLY PHARM) APPROVAL= AP YEAR= 2026
NDA 214880 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (MICRO LABS) APPROVAL= AP YEAR= 2026
NDA 218249 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (HAINAN POLY) APPROVAL= AP YEAR= 2026
NDA 219583 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (SHANDONG NEW TIME PHARMACEUTICAL CO LTD) APPROVAL= TA YEAR= 2026
NDA 219772 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (ALKEM LABS LTD) APPROVAL= AP YEAR= 2026
NDA 219952 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (SCIEGEN PHARMS) APPROVAL= AP YEAR= 2026
NDA 220164 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (LUPIN) APPROVAL= AP YEAR= 2026
NDA 220385 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (REGCON HOLDINGS) APPROVAL= AP YEAR= 2026
NDA 220470 (pdf not found) INN (BRIVARACETAM) BRIVARACETAM (CENTAUR PHARMS PVT) APPROVAL= AP YEAR= 2026