e-Drug3D

1790

M SACUBITRIL

INN
SACUBITRIL

cas 149709-44-4

CLASS

CARDIOVASCULAR
NEUTRAL ENDOPEPTIDASE NEPRILYSIN (NEP) INHIBITOR
TREATMENT OF PATIENTS WITH CHRONIC HEART FAILURE

ROUTE (list)

ATC code

C09DX04

PK parameters

Tmax 2 HOUR
PPB 94 PERCENT
t1/2 11.5 HOUR

Target

TARGET NEPRILYSIN

PDB
5JMY (NEPRILYSIN COMPLEXED WITH LBQ657)

Download experimental 3D coordinates of 6LD with added hydrogens

Neprilysin UNIPROT P08473 MME

Download SDF file

[1,1'-Biphenyl]-4-pentanoic acid, gamma-[(3-carboxy-1-oxopropyl)amino]-alpha-methyl-, (alphaR,gammaS)-

Formula:
C22H25NO5

Calculated chemical properties:

MW 381.41
NB_atoms 28
XLogP 0.69
PSA 98.806
NB_HD 1
NB_HA 6
fsp3 0.32
Lipinski(0=no;1=yes) 1

FDA
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