e-Drug3D

1785

DACLATASVIR

DISCONTINUED

INN
DACLATASVIR

cas 1009119-64-5

CLASS

ANTIINFECTIVES
INHIBITOR OF HCV NONSTRUCTURAL PROTEIN 5A (NS5A)

ROUTE (list)

ORAL

ATC code

J05AP07
J05AP58

PK parameters

F 67 PERCENT
Tmax 2 HOUR
VD 47 LITER
Cl 4.2 LITER / HOUR
PPB 99 PERCENT
t1/2 13.5 HOUR

Solubility

FREELY SOLUBLE IN WATER

Target

TARGET NS5A

DrugCentral

Genome polyprotein UNIPROT P26663

Genome polyprotein UNIPROT P27958

Download SDF file

Carbamic acid, N,N'-[[1,1'-biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-, C,C'-dimethyl ester

Formula:
C40H50N8O6

Calculated chemical properties:

MW 738.88
NB_atoms 54
XLogP 6.22
PSA 154.68
NB_HD 4
NB_HA 14
fsp3 0.45
Lipinski(0=no;1=yes) 0

FDA
NDA 206843 (label) INN (DACLATASVIR DIHYDROCHLORIDE) DAKLINZA (BRISTOL-MYERS SQUIBB) APPROVAL= AP YEAR= 2015 DISCONTINUED