e-Drug3D

1784

DEOXYCHOLIC ACID

INN
DEOXYCHOLIC ACID

cas 83-44-3

CLASS

DERMATOLOGICAL
CYTOLYTIC DRUG
DESTROYS THE CELL MEMBRANE CAUSING LYSIS
TREATMENT OF MODERATE TO SEVERE CONVEXITY OR FULLNESS ASSOCIATED WITH SUBMENTAL FAT

ROUTE (list)

SUBCUTANEOUS

NATURAL MOLECULE (link)

ATC code

D11AX24

PK parameters

Tmax 0.3 HOUR
Cmax 2.6 MICROMOLAR
PPB 98 PERCENT

Target

PDB
OBSOLETE (- 1WB2 CRYSTAL STRUCTURE OF TRANSLATION ELONGATION FACTOR SELB FROM METHANOCOCCUS MARIPALUDIS, APO FORM)

Ligand code = DXC (link to the list of PDB complexes)

Download experimental 3D coordinates of DXC with added hydrogens

DrugCentral

Unknown

Download SDF file

Cholan-24-oic acid, 3,12-dihydroxy-, (3alpha,5beta,12alpha)-

Formula:
C24H40O4

Calculated chemical properties:

MW 391.55
NB_atoms 28
XLogP 3.14
PSA 76.045
NB_HD 2
NB_HA 4
fsp3 0.96
Lipinski(0=no;1=yes) 1

FDA
NDA 206333 (label) INN (DEOXYCHOLIC ACID) KYBELLA (ABBVIE) APPROVAL= AP YEAR= 2015
NDA 212296 (pdf not found) INN (DEOXYCHOLIC ACID) DEOXYCHOLIC ACID (WILSHIRE PHARMS INC) APPROVAL= AP YEAR= 2021