e-Drug3D

1781

CHOLIC ACID

INN
CHOLIC ACID

cas 81-25-4

CLASS

METABOLISM
TREATMENT OF BILE ACID SYNTHESIS DISORDERS
ADJUNCTIVE TREATMENT OF PEROXISOMAL DISORDERS (PDS) INCLUDING ZELLWEGER SPECTRUM DISEASE

ROUTE (list)

ORAL

ATC code

A05AA03

PK parameters

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET FXR

G-protein coupled bile acid receptor 1 UNIPROT Q8TDU6 GPBAR1

Download SDF file

Cholan-24-oic acid, 3,7,12-trihydroxy-, (3alpha,5beta,7alpha,12alpha)-

Formula:
C24H40O5

Calculated chemical properties:

MW 407.55
NB_atoms 29
XLogP 2.11
PSA 93.434
NB_HD 3
NB_HA 5
fsp3 0.96
Lipinski(0=no;1=yes) 1

FDA
NDA 205750 (label) INN (CHOLIC ACID) CHOLBAM (MIRUM) APPROVAL= AP YEAR= 2015 NEWMOLECULARENTITY