e-Drug3D

1753

cas 911-45-5

CLASS

GENITO
INITIATION OF OVULATION
FERTILITY AGENTS, FEMALE
ESTROGEN RECEPTOR ANTAGONIST
ZUCLOMIPHENE (CIS) HAS A LONGER HALF-LIFE THAN ENCLOMIPHENE (TRANS)

ROUTE (list)

ORAL

PK parameters

TARGET ESTROGEN RECEPTOR

PDB
6VPF (ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH THE SELECTIVE ESTROGEN RECEPTOR MODULATOR CLOMIPHENE)

Ligand code = 53Q (link to the list of PDB complexes)

Download experimental 3D coordinates of 53Q with added hydrogens

MW 405.94
NB_atoms 29
XLogP 6.56
PSA 13.765
NB_HD 0
NB_HA 2
fsp3 0.23
Lipinski(0=no;1=yes) 0

FDA
NDA 016131 (label) INN (CLOMIPHENE CITRATE) CLOMID (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1967 NEWMOLECULARENTITY DISCONTINUED
NDA 018361 (pdf not found) INN (CLOMIPHENE CITRATE) SEROPHENE (EMD SERONO) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 072196 (pdf not found) INN (CLOMIPHENE CITRATE) MILOPHENE (GRANATA BIO CORP) APPROVAL= AP YEAR= 1988
NDA 075528 (pdf not found) INN (CLOMIPHENE CITRATE) CLOMIPHENE CITRATE (COSETTE) APPROVAL= AP YEAR= 1999
NDA 216545 (pdf not found) INN (CLOMIPHENE CITRATE) CLOMIPHENE CITRATE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2024
NDA 216739 (pdf not found) INN (CLOMIPHENE CITRATE) CLOMIPHENE CITRATE (APPCO) APPROVAL= AP YEAR= 2024
NDA 219406 (pdf not found) INN (CLOMIPHENE CITRATE) CLOMIPHENE CITRATE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2025
NDA 219781 (pdf not found) INN (CLOMIPHENE CITRATE) CLOMIPHENE CITRATE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2025
NDA 220673 (pdf not found) INN (CLOMIPHENE CITRATE) CLOMIPHENE CITRATE (ASCENT PHARMS INC) APPROVAL= AP YEAR= 2026