e-Drug3D

1745

cas 571190-30-2

CLASS

ANTINEOPLASTIC
TREATMENT OF BREAST CANCER
CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS

ROUTE (list)

ORAL

PK parameters

F 46 PERCENT
Tmax 9 HOUR
VD 2583 LITER
Cl 63.1 LITER / HOUR
PPB 85 PERCENT
t1/2 29 HOUR

TARGET CYCLIN-DEPENDENT KINASE (CDK) 4
CYCLIN-DEPENDENT KINASE (CDK) 6

PDB
2EUF (X-RAY STRUCTURE OF HUMAN CDK6-VCYCLIN IN COMPLEX WITH THE INHIBITOR PD0332991)

Ligand code = LQQ (link to the list of PDB complexes)

Download experimental 3D coordinates of LQQ with added hydrogens

MW 447.54
NB_atoms 33
XLogP 2.97
PSA 90.595
NB_HD 2
NB_HA 9
fsp3 0.46
Lipinski(0=no;1=yes) 1

FDA
NDA 207103 (label) INN (PALBOCICLIB) IBRANCE (PFIZER) APPROVAL= AP YEAR= 2015
NDA 212436 (label) INN (PALBOCICLIB) IBRANCE (PFIZER) APPROVAL= AP YEAR= 2019
NDA 213107 (pdf not found) INN (PALBOCICLIB) PALBOCICLIB (SUN PHARM INDS LTD) APPROVAL= TA YEAR= 2021
NDA 213091 (pdf not found) INN (PALBOCICLIB) PALBOCICLIB (DR REDDYS LABS LTD) APPROVAL= TA YEAR= 2021
NDA 213086 (pdf not found) INN (PALBOCICLIB) PALBOCICLIB (EUGIA PHARMA SPECLTS) APPROVAL= TA YEAR= 2022
NDA 213152 (pdf not found) INN (PALBOCICLIB) PALBOCICLIB (AIZANT DRUG RESEARCH SOLUTIONS PVT LTD) APPROVAL= TA YEAR= 2022
NDA 214758 (pdf not found) INN (PALBOCICLIB) PALBOCICLIB (MSN PHARMACEUTICALS INC) APPROVAL= TA YEAR= 2023
NDA 215570 (pdf not found) INN (PALBOCICLIB) PALBOCICLIB (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 217365 (pdf not found) INN (PALBOCICLIB) PALBOCICLIB CAPSULES (CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.) APPROVAL= TA YEAR= 2025
NDA 212980 (pdf not found) INN (PALBOCICLIB) PALBOCICLIB (CIPLA LIMITED) APPROVAL= TA YEAR= 2026
NDA 213089 (pdf not found) INN (PALBOCICLIB) PALBOCICLIB (NATCO PHARMA LTD) APPROVAL= TA YEAR= 2026
NDA 220444 (pdf not found) INN (PALBOCICLIB) PALBOCICLIB (DR. REDDY'S LABORATORIES LIMITED) APPROVAL= TA YEAR= 2026