e-Drug3D

1744

PANOBINOSTAT

DISCONTINUED

INN
PANOBINOSTAT

cas 404950-80-7

CLASS

ANTINEOPLASTIC
HISTONE DEACETYLASE (HDAC) INHIBITOR
TREATMENT OF MULTIPLE MYELOMA

ROUTE (list)

ORAL

ATC code

L01XH03

PK parameters

F 21 PERCENT
Tmax 2 HOUR
VD 1000 LITER
Cl 160 LITER / HOUR
PPB 90 PERCENT
t1/2 37 HOUR

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

TARGET HISTONE DEACETYLASE

PDB
5EF8 (CRYSTAL STRUCTURE OF DANIO RERIO HISTONE DEACETYLASE 6 CATALYTIC DOMAIN 2 IN COMPLEX WITH PANOBINOSTAT)

Download experimental 3D coordinates of LBH with added hydrogens

Histone deacetylase 5 UNIPROT Q9UQL6 HDAC5

Histone deacetylase 2 UNIPROT Q92769 HDAC2

Download SDF file

2-Propenamide, N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-

Formula:
C21H23N3O2

Calculated chemical properties:

MW 349.42
NB_atoms 26
XLogP 3.33
PSA 82.424
NB_HD 4
NB_HA 5
fsp3 0.19
Lipinski(0=no;1=yes) 1

FDA
NDA 205353 (label) INN (PANOBINOSTAT LACTATE) FARYDAK (SECURA) APPROVAL= AP YEAR= 2015 NEWMOLECULARENTITY DISCONTINUED