e-Drug3D

1742

EDOXABAN

INN
EDOXABAN

cas 480449-70-5

CLASS

CARDIOVASCULAR
FACTOR XA INHIBITOR
TO REDUCE THE RISK OF STROKE AND SYSTEMIC EMBOLISM
TREATMENT OF DEEP VEIN THROMBOSIS AND PULMONARY EMBOLISM

ROUTE (list)

ORAL

ATC code

B01AF03

PK parameters

F 62 PERCENT
Tmax 1.5 HOUR
VD 107 LITER
Cl 22 LITER / HOUR
PPB 55 PERCENT
t1/2 12 HOUR

Solubility

VERY SLIGHTLY SOLUBLE AT PH 6-7

Target

TARGET FACTOR XA

DrugCentral

Coagulation factor X UNIPROT P00742 F10

Download SDF file

Ethanediamide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-

Formula:
C24H30ClN7O4S

Calculated chemical properties:

MW 548.07
NB_atoms 37
XLogP 1.29
PSA 125.113
NB_HD 3
NB_HA 11
fsp3 0.50
Lipinski(0=no;1=yes) 0

FDA
NDA 206316 (label) INN (EDOXABAN TOSYLATE) SAVAYSA (DAIICHI SANKYO INC) APPROVAL= AP YEAR= 2015
NDA 213064 (pdf not found) INN (EDOXABAN) EDOXABAN (ZYDUS PHARMS USA INC) APPROVAL= TA YEAR= 2022