e-Drug3D
173
cas 83-88-5
CLASS
METABOLISM
PHOTOSENSITIZING AGENTS
VITAMIN B2
ANTIMALARIALS
ROUTE (list)
INJECTION INTRAVENOUS
PK parameters
Tmax 2 HOUR
VD 39.6 LITER (65 KILOGRAM)
Cl 29.3 LITER / HOUR
PPB 35.5 PERCENT
t1/2 0.93 HOUR (EQN)
TARGET FLAVOKINASE
FLAVIN ADENIN DINUCLEOTIDE (FAD) SYNTHASE
FLAVIN ADENIN DINUCLEOTIDE (FAD) SYNTHASE
PDB
2CCB (COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS)
Ligand code = RBF (link to the list of PDB complexes)
Download experimental 3D coordinates of RBF with added hydrogens
Riboflavin kinase K UNIPROT Q969G6 RFK
Formula:
C17H20N4O6
Calculated chemical properties:
MW 376.37
NB_atoms 27
XLogP -1.72
PSA 147.833
NB_HD 5
NB_HA 10
fsp3 0.41
Lipinski(0=no;1=yes) 0
NB_atoms 27
XLogP -1.72
PSA 147.833
NB_HD 5
NB_HA 10
fsp3 0.41
Lipinski(0=no;1=yes) 0
FDA
NDA 008809 (label) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E) M.V.I.-12 ADULT (HOSPIRA) APPROVAL= AP YEAR= 1953 DISCONTINUED
NDA 020176 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PANTOTHENIC ACID ; PHYTONADIONE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; VITAMIN A PALMITATE ; VITAMIN E) VITAPED (HOSPIRA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 021265 (label) INN (ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; TOCOPHEROL ACETATE ; VITAMIN A ; VITAMIN K) INFUVITE PEDIATRIC (SANDOZ CANADA INC) APPROVAL= AP YEAR= 2001
NDA 021646 (label) INN (RIBOFLAVIN) INFUVITE PEDIATRIC PHARMACY BULK PACKAGE (SANDOZ INC) APPROVAL= AP YEAR= 2004 OBSOLETE
NDA 210456 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; TOCOPHEROL ACETATE ; VITAMIN A ; VITAMIN K) MULTIPLE VITAMINS INJECTION PEDIATRIC PHARMACY BULK PACKAGE (APOTEX) APPROVAL= AP YEAR= 2026
NDA 210671 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; TOCOPHEROL ACETATE ; VITAMIN A ; VITAMIN K) MULTIPLE VITAMINS INJECTION PEDIATRIC (APOTEX) APPROVAL= AP YEAR= 2026
NDA 008809 (label) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E) M.V.I.-12 ADULT (HOSPIRA) APPROVAL= AP YEAR= 1953 DISCONTINUED
NDA 020176 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PANTOTHENIC ACID ; PHYTONADIONE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; VITAMIN A PALMITATE ; VITAMIN E) VITAPED (HOSPIRA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 021265 (label) INN (ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; TOCOPHEROL ACETATE ; VITAMIN A ; VITAMIN K) INFUVITE PEDIATRIC (SANDOZ CANADA INC) APPROVAL= AP YEAR= 2001
NDA 021646 (label) INN (RIBOFLAVIN) INFUVITE PEDIATRIC PHARMACY BULK PACKAGE (SANDOZ INC) APPROVAL= AP YEAR= 2004 OBSOLETE
NDA 210456 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; TOCOPHEROL ACETATE ; VITAMIN A ; VITAMIN K) MULTIPLE VITAMINS INJECTION PEDIATRIC PHARMACY BULK PACKAGE (APOTEX) APPROVAL= AP YEAR= 2026
NDA 210671 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CHOLECALCIFEROL ; CYANOCOBALAMIN ; DEXPANTHENOL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; TOCOPHEROL ACETATE ; VITAMIN A ; VITAMIN K) MULTIPLE VITAMINS INJECTION PEDIATRIC (APOTEX) APPROVAL= AP YEAR= 2026