e-Drug3D

1588

ACLIDINIUM

INN
ACLIDINIUM

cas 727649-81-2

CLASS

RESPIRATORY SYSTEM
ANTICHOLINERGIC
MUSCARINIC RECEPTOR ANTAGONIST
CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
INHIBITION OF M3 RECEPTOR AT THE SMOOTH MUSCLE LEADING TO BRONCHODILATION

ROUTE (list)

INHALATION

ATC code

R03BB05
R03AL05

PK parameters

F 6 PERCENT
Tmax 0.16 HOUR
VD 300 LITER (INTRAVENOUS ADMINISTRATION OF 400 MCG)
Cl 170 LITER / HOUR
t1/2 6.5 HOUR

Solubility

VERY SLIGHTLY SOLUBLE IN WATER

Target

TARGET MUSCARINIC RECEPTORS (M1 TO M5)

DrugCentral

Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3

Download SDF file

1-Azoniabicyclo[2.2.2]octane, 3-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-1-(3-phenoxypropyl)-, (3R)-

Formula:
C26H30NO4S2

Calculated chemical properties:

MW 484.65
NB_atoms 33
XLogP 4.67
PSA 55.217
NB_HD 1
NB_HA 4
fsp3 0.42
Lipinski(0=no;1=yes) 1

FDA
NDA 202450 (label) INN (ACLIDINIUM BROMIDE) TUDORZA PRESSAIR (AZURITY) APPROVAL= AP YEAR= 2012 NEWMOLECULARENTITY
NDA 210595 (label) INN (ACLIDINIUM BROMIDE ; FORMOTEROL FUMARATE) DUAKLIR PRESSAIR (AZURITY) APPROVAL= AP YEAR= 2019