e-Drug3D

1586

ELVITEGRAVIR

INN
ELVITEGRAVIR

cas 697761-98-1

CLASS

ANTIINFECTIVES
TREATMENT OF HIV-1 INFECTION
INHIBITOR

ROUTE (list)

ORAL

ATC code

J05AJ02
J05AR18
J05AR09

PK parameters

Tmax 4 HOUR
Cmax 3.8 MICROMOLAR
PPB 98 PERCENT
t1/2 12.9 HOUR

Solubility

LESS THAN 0.3 MICROGRAMS PER ML IN WATER

Target

TARGET VIRAL INTEGRASE

PDB
3L2U (CRYSTAL STRUCTURE OF THE PROTOTYPE FOAMY VIRUS (PFV) INTASOME IN COMPLEX WITH MAGNESIUM AND GS9137 (ELVITEGRAVIR))

Ligand code = ELV (link to the list of PDB complexes)

Download experimental 3D coordinates of ELV with added hydrogens

DrugCentral

Integrase UNIPROT Q7ZJM1 pol

Download SDF file

3-Quinolinecarboxylic acid, 6-[(3-chloro-2-fluorophenyl)methyl]-1,4-dihydro-1-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-

Formula:
C23H23ClFNO5

Calculated chemical properties:

MW 446.87
NB_atoms 31
XLogP 2.95
PSA 77.45
NB_HD 1
NB_HA 6
fsp3 0.30
Lipinski(0=no;1=yes) 1

FDA
NDA 203100 (label) INN (COBICISTAT ; ELVITEGRAVIR ; EMTRICITABINE ; TENOFOVIR DISOPROXIL FUMARATE) STRIBILD (GILEAD SCIENCES INC) APPROVAL= AP YEAR= 2012
NDA 203093 (label) INN (ELVITEGRAVIR) VITEKTA (GILEAD SCIENCES INC) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 207561 (label) INN (COBICISTAT ; ELVITEGRAVIR ; EMTRICITABINE ; TENOFOVIR ALAFENAMIDE FUMARATE) GENVOYA (GILEAD SCIENCES INC) APPROVAL= AP YEAR= 2015
NDA 218575 (pdf not found) INN (ELVITEGRAVIR ; COBICISTAT ; EMTRICITABINE ; TENOFOVIR ALAFENAMIDE) ELVITEGRAVIR, COBICISTAT, EMTRICITABINE AND TENOFOVIR ALAFENAMIDE (APOTEX INC) APPROVAL= TA YEAR= 2026