e-Drug3D

1582

M LINACLOTIDE

INN
LINACLOTIDE

(is an active metabolite)

cas 851199-59-2

CLASS

METABOLISM
GUANYLATE CYCLASE-C AGONIST
IRRITABLE BOWEL SYNDROME WITH CONSTIPATION
CHRONIC IDIOPATHIC CONSTIPATION

ROUTE (list)

ATC code

A06AX04

PK parameters

Target

TARGET GUANYLATE CYCLASE-C (GC-C)

DrugCentral

Heat-stable enterotoxin receptor UNIPROT P25092 GUCY2C

Download SDF file

L-cysteinyl-L-cysteinyl-L-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-Lasparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl-L-cysteinyl, cyclic (1-6), (2-10), (513)-tris (disulfide)

Formula:
C50H70N14O19S6

Calculated chemical properties:

MW 1361.60
NB_atoms 89
XLogP -9.04
PSA 482.491
NB_HD 17
NB_HA 33
fsp3 0.58
Lipinski(0=no;1=yes) 0

FDA
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