e-Drug3D

1579

PERAMPANEL

INN
PERAMPANEL

cas 380917-97-5

CLASS

NERVOUS SYSTEM
ANTIEPILEPTICS
NON-COMPETITIVE AMPA GLUTAMATE RECEPTOR ANTAGONIST
TREATMENT OF PARTIAL-ONSET SEIZURES

ROUTE (list)

ORAL

ATC code

N03AX22

PK parameters

Cl 0.72 LITER / HOUR
PPB 95 PERCENT
t1/2 105 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET AMPA GLUTAMATE RECEPTOR

PDB
5L1F (AMPA SUBTYPE IONOTROPIC GLUTAMATE RECEPTOR GLUA2 IN COMPLEX WITH NONCOMPETITIVE INHIBITOR PERAMPANEL)

Ligand code = 6ZP (link to the list of PDB complexes)

Download experimental 3D coordinates of 6ZP with added hydrogens

DrugCentral

Glutamate receptor ionotropic AMPA UNIPROT P42261 GRIA1

Download SDF file

Benzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)-

Formula:
C23H15N3O

Calculated chemical properties:

MW 349.38
NB_atoms 27
XLogP 4.44
PSA 46.796
NB_HD 0
NB_HA 4
fsp3 0.00
Lipinski(0=no;1=yes) 1

FDA
NDA 202834 (label) INN (PERAMPANEL) FYCOMPA (CATALYST PHARMS) APPROVAL= AP YEAR= 2012 NEWMOLECULARENTITY
NDA 208277 (label) INN (PERAMPANEL) FYCOMPA (CATALYST PHARMS) APPROVAL= AP YEAR= 2016
NDA 209877 (pdf not found) INN (PERAMPANEL) PERAMPANEL (ACCORD HLTHCARE) APPROVAL= TA YEAR= 2021
NDA 209538 (pdf not found) INN (PERAMPANEL) PERAMPANEL (TARO) APPROVAL= AP YEAR= 2025
NDA 209801 (pdf not found) INN (PERAMPANEL) PERAMPANEL (TEVA PHARMS USA INC) APPROVAL= AP YEAR= 2025
NDA 218152 (pdf not found) INN (PERAMPANEL) PERAMPANEL (MSN) APPROVAL= AP YEAR= 2025
NDA 218178 (pdf not found) INN (PERAMPANEL) PERAMPANEL (MSN) APPROVAL= AP YEAR= 2025
NDA 219052 (pdf not found) INN (PERAMPANEL) PERAMPANEL (TARO) APPROVAL= AP YEAR= 2026