1574

INN
ICOSAPENT

(is an active metabolite)

CARDIOVASCULAR
ADJUNCT TO DIET TO REDUCE TRIGLYCERIDE (TG) LEVELS IN ADULT PATIENTS WITH SEVERE (>= 500 MG/DL) HYPERTRIGLYCERIDEMIA
POTENTIAL MECHANISMS OF ACTION INCLUDE INCREASED BETA-OXIDATION
INHIBITION OF ACYL-COA:1,2-DIACYLGLYCEROL ACYLTRANSFERASE (DGAT)
DECREASED LIPOGENESIS IN THE LIVER
AND INCREASED PLASMA LIPOPROTEIN LIPASE ACTIVITY

-

VD 88 LITER
Cl 0.68 LITER / HOUR
PPB 99 PERCENT
t1/2 89 HOUR

PDB
1IGX (CRYSTAL STRUCTURE OF EICOSAPENTANOIC ACID BOUND IN THE CYCLOOXYGENASE CHANNEL OF PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1.)

Ligand code = EPA (link to the list of PDB complexes)

Download experimental 3D coordinates of EPA with added hydrogens