e-Drug3D

1563

M SILDENAFIL

INN
SILDENAFIL

cas 139755-82-1

CLASS

GENITO
ERECTILE DYSFUNCTION (THERAPEUTIC)
SPECIFIC PHOSPHODIESTERASE INHIBITORS
VASODILATOR AGENTS
THE METABOLITE ACCOUNTS FOR ABOUT 20 PERCENT OF SILDENAFIL PHARMACOLOGIC
TREATMENT OF PULMONARY ARTERIAL HYPERTENSION (PAH) (DRUG FOR RARE DISEASE IN EUROPE)

ROUTE (list)

ATC code

G04BE03

PK parameters

Target

TARGET PHOSPHODIESTERASE TYPE 5 (PDE5)

DrugCentral

cGMP-specific 3,5-cyclic phosphodiesterase UNIPROT O76074 PDE5A

Download SDF file

7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-(1-piperazinylsulfonyl)phenyl]-1,6-dihydro-1-methyl-3-propyl-

Formula:
C21H28N6O4S

Calculated chemical properties:

MW 460.56
NB_atoms 32
XLogP 1.27
PSA 110.284
NB_HD 2
NB_HA 10
fsp3 0.48
Lipinski(0=no;1=yes) 1

FDA
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