e-Drug3D

1532

cas 873054-44-5

CLASS

RESPIRATORY SYSTEM
CYSTIC FIBROSIS
POTENTIATOR

ROUTE (list)

ORAL

PK parameters

Cmax 1.95 MICROMOLAR (150 MILLIGRAM)
VD 353 LITER (150 MILLIGRAM EVERY 12 HOURS DURING 7 DAYS)
Cl 17.3 LITER / HOUR (150 MILLIGRAM)
PPB 99 PERCENT
t1/2 12 HOUR (150 MILLIGRAM)

TARGET G551D-CFTR CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

PDB
6O2P (COMPLEX OF IVACAFTOR WITH CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR))

Ligand code = VX7 (link to the list of PDB complexes)

Download experimental 3D coordinates of VX7 with added hydrogens

MW 392.48
NB_atoms 29
XLogP 5.08
PSA 61.003
NB_HD 3
NB_HA 5
fsp3 0.33
Lipinski(0=no;1=yes) 0

FDA
NDA 203188 (label) INN (IVACAFTOR) KALYDECO (VERTEX PHARMS) APPROVAL= AP YEAR= 2012
NDA 206038 (label) INN (IVACAFTOR ; LUMACAFTOR) ORKAMBI (VERTEX PHARMS INC) APPROVAL= AP YEAR= 2015
NDA 207925 (label) INN (IVACAFTOR) KALYDECO (VERTEX PHARMS INC) APPROVAL= AP YEAR= 2015
NDA 210491 (label) INN (IVACAFTOR ; TEZACAFTOR) SYMDEKO COPACKAGED (VERTEX PHARMS INC) APPROVAL= AP YEAR= 2018
NDA 211358 (label) INN (IVACAFTOR ; LUMACAFTOR) ORKAMBI (VERTEX PHARMS INC) APPROVAL= AP YEAR= 2018
NDA 212273 (label) INN (ELEXACAFTOR ; IVACAFTOR ; TEZACAFTOR) TRIKAFTA COPACKAGED (VERTEX PHARMS INC) APPROVAL= AP YEAR= 2019
NDA 216074 (pdf not found) INN (IVACAFTOR) IVACAFTOR (LUPIN LTD) APPROVAL= TA YEAR= 2022
NDA 217660 (label) INN (ELEXACAFTOR ; IVACAFTOR ; TEZACAFTOR) TRIKAFTA COPACKAGED (VERTEX PHARMS INC) APPROVAL= AP YEAR= 2023
NDA 218730 (label) INN (IVACAFTOR ; TEZACAFTOR ; VANZACAFTOR CALCIUM) ALYFTREK (VERTEX PHARMS INC) APPROVAL= AP YEAR= 2024 NEWMOLECULARENTITY
NDA 217431 (pdf not found) INN (IVACAFTOR) IVACAFTOR (LUPIN LTD) APPROVAL= TA YEAR= 2025