e-Drug3D

1511

VILAZODONE

INN
VILAZODONE

cas 163521-12-8

CLASS

NERVOUS SYSTEM
MAJOR DEPRESSIVE DISORDER (MDD)
SEROTONIN REUPTAKE INHIBITOR
5-HT1A PARTIAL AGONIST
AFFINITY FOR SEROTONIN REUPTAKE SITE (KI= 0.1 NM)
PARTIAL AGONIST OF SEROTONERGIC 5-HT1A RECEPTORS (IC50=2.1 NM)

ROUTE (list)

ORAL

ATC code

N06AX24

PK parameters

F 72 PERCENT
Tmax 4.5 HOUR
Cmax 0.35 MICROMOLAR (40 MILLIGRAM)
PPB 98 PERCENT
t1/2 25 HOUR

Target

TARGET SEROTONIN REUPTAKE

PDB
8FYL (VILAZODONE-BOUND SEROTONIN 1A (5-HT1A) RECEPTOR-GI1 PROTEIN COMPLEX)

Ligand code = YG7 (link to the list of PDB complexes)

Download experimental 3D coordinates of YG7 with added hydrogens

DrugCentral

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4

5-hydroxytryptamine receptor 1A UNIPROT P08908 HTR1A

Download SDF file

2-Benzofurancarboxamide, 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-

Formula:
C26H27N5O2

Calculated chemical properties:

MW 441.53
NB_atoms 33
XLogP 4.03
PSA 96.883
NB_HD 3
NB_HA 7
fsp3 0.31
Lipinski(0=no;1=yes) 1

FDA
NDA 022567 (label) INN (VILAZODONE HYDROCHLORIDE) VIIBRYD (ABBVIE) APPROVAL= AP YEAR= 2011
NDA 208212 (pdf not found) INN (VILAZODONE HYDROCHLORIDE) VILAZODONE HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2019
NDA 208202 (pdf not found) INN (VILAZODONE HYDROCHLORIDE) VILAZODONE HYDROCHLORIDE (ALEMBIC) APPROVAL= AP YEAR= 2020
NDA 208200 (pdf not found) INN (VILAZODONE HYDROCHLORIDE) VILAZODONE HYDROCHLORIDE (INVAGEN PHARMS) APPROVAL= AP YEAR= 2021
NDA 208209 (pdf not found) INN (VILAZODONE HYDROCHLORIDE) VILAZODONE HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2021
NDA 208228 (pdf not found) INN (VILAZODONE HYDROCHLORIDE) VILAZODONE HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 2023