e-Drug3D

1480

TELAVANCIN

INN
TELAVANCIN

cas 372151-71-8

CLASS

ANTIINFECTIVE
LIPOGLYCOPEPTIDE ANTIBACTERIALS
SKIN INFECTION
GRAM-POSITIVE BACTERIA
SYNTHETIC DERIVATIVE OF VANCOMYCIN
INHIBITS BACTERIAL CELL WALL SYNTHESIS BY INTERFERING WITH THE POLYMERIZATION AND CROSS-LINKING OF PEPTIDOGLYCAN

ROUTE (list)

INTRAVENOUS INJECTION

ATC code

J01XA03

PK parameters

VD 9.4 LITER (65 KILOGRAM)
Cl 0.9 LITER / HOUR (65 KILOGRAM)
PPB 90 PERCENT
t1/2 8 HOUR

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

DrugCentral

Unknown

Download SDF file

Vancomycin, N3''-[2-(decylamino)ethyl]-29-[[(phosphonomethyl)amino]methyl]- (REACH)

Formula:
C80H106Cl2N11O27P

Calculated chemical properties:

MW 1752.60
NB_atoms 121
XLogP 0.09
PSA 547.601
NB_HD 21
NB_HA 38
fsp3 0.53
Lipinski(0=no;1=yes) 0

FDA
NDA 022110 (label) INN (TELAVANCIN HYDROCHLORIDE) VIBATIV (CUMBERLAND) APPROVAL= AP YEAR= 2009 NEWMOLECULARENTITY
NDA 022407 (label) INN (TELAVANCIN) VIBATIV (THERAVANCE INC) APPROVAL= AP YEAR= 2013 NEWAPPLICATION