e-Drug3D

1475

cas 147511-69-1

CLASS

HMG-COA REDUCTASE INHIBITOR
ANTIHYPERLIPIDEMIC
CARDIOVASCULAR
LIPID-LOWERING AGENT

ROUTE (list)

ORAL

PK parameters

F 51 PERCENT
VD 148 LITER
Cl 8.5 LITER / HOUR (EQN)
PPB 99 PERCENT
t1/2 12 HOUR

TARGET 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA)

PDB
7ULM (COMPLEX OF HMG1 WITH PITAVASTATIN)

Ligand code = PV9 (link to the list of PDB complexes)

Download experimental 3D coordinates of PV9 with added hydrogens

MW 420.44
NB_atoms 31
XLogP 3.18
PSA 81.192
NB_HD 2
NB_HA 5
fsp3 0.28
Lipinski(0=no;1=yes) 1

FDA
NDA 022363 (label) INN (PITAVASTATIN CALCIUM) LIVALO (KOWA CO) APPROVAL= AP YEAR= 2009
NDA 206015 (label) INN (PITAVASTATIN CALCIUM) PITAVASTATIN CALCIUM (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2016
NDA 205932 (pdf not found) INN (PITAVASTATIN CALCIUM) PITAVASTATIN CALCIUM (ORIENT PHARMA CO LTD) APPROVAL= AP YEAR= 2017
NDA 205955 (pdf not found) INN (PITAVASTATIN CALCIUM) PITAVASTATIN CALCIUM (SAWAI USA) APPROVAL= AP YEAR= 2017
NDA 208379 (label) INN (PITAVASTATIN MAGNESIUM) ZYPITAMAG (MEDICURE) APPROVAL= AP YEAR= 2017
NDA 209875 (label) INN (PITAVASTATIN SODIUM) NIKITA (LUPIN) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 206070 (pdf not found) INN (PITAVASTATIN CALCIUM) PITAVASTATIN CALCIUM (MYLAN) APPROVAL= AP YEAR= 2019
NDA 206029 (pdf not found) INN (PITAVASTATIN CALCIUM) PITAVASTATIN CALCIUM (LUPIN) APPROVAL= AP YEAR= 2023
NDA 206047 (pdf not found) INN (PITAVASTATIN CALCIUM) PITAVASTATIN CALCIUM (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023
NDA 205977 (pdf not found) INN (PITAVASTATIN CALCIUM) PITAVASTATIN CALCIUM (HETERO LABS LTD V) APPROVAL= AP YEAR= 2024
NDA 205961 (pdf not found) INN (PITAVASTATIN CALCIUM) PITAVASTATIN CALCIUM (AMNEAL PHARMS NY) APPROVAL= AP YEAR= 2024