e-Drug3D

1444

PLICAMYCIN

DISCONTINUED

INN
PLICAMYCIN

cas 18378-89-7

CLASS

ANTINEOPLASTIC
CYTOTOXIC ANTIBIOTICS PRODUCED BY STREPTOMYCES ARGILLACEUS

ROUTE (list)

INJECTION

NATURAL MOLECULE (link)

ATC code

L01DC02

PK parameters

Target

TARGET DNA

PDB
6VGG (CRYSTAL STRUCTURE OF THE DNA BINDING DOMAINS OF HUMAN TRANSCRIPTION FACTOR ERG, HUMAN RUNX2 BOUND TO CORE BINDING FACTOR BETA (CBFB), AND MITHRAMYCIN, IN COMPLEX WITH 16MER DNA CAGAGGATGTGGCTTC)

Ligand code = QWP (link to the list of PDB complexes)

Download experimental 3D coordinates of QWP with added hydrogens

DrugCentral

Unknown

Download SDF file

D-threo-2-Pentulose, 5-deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-.beta.-D-arabino-hexopyranosyl)-.beta.-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-.beta.-D-ribo-hexopyranosyl-(13)-O-2,6-dideoxy-.beta.-D-lyxo-hexopyranosyl-(13)-2,6-dideoxy-.beta.-D-arabino-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-, (1S)- (9CI)

Formula:
C52H76O24

Calculated chemical properties:

MW 1085.13
NB_atoms 76
XLogP -0.25
PSA 346.579
NB_HD 11
NB_HA 24
fsp3 0.77
Lipinski(0=no;1=yes) 0

FDA
NDA 050109 (pdf not found) INN (PLICAMYCIN) MITHRACIN (PFIZER) APPROVAL= AP YEAR= 1970 NEWMOLECULARENTITY DISCONTINUED