e-Drug3D

1433

cas 93413-62-8

CLASS

NERVOUS SYSTEM
ANTIDEPRESSANTS
SELECTIVE SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITOR (SNRI)
TREATMENT OF MAJOR DEPRESSIVE DISORDER [MDD]

ROUTE (list)

ORAL

PK parameters

F 80 PERCENT
Tmax 3 HOUR
Cmax 1.1 MICROMOLAR
VD 370 LITER (65 KILOGRAM)
Cl 26 LITER / HOUR (65 KILOGRAM)
PPB 30 PERCENT
t1/2 11 HOUR

TARGET SEROTONIN AND NOREPINEPHRINE REUPTAKE

PDB
4MMC (CRYSTAL STRUCTURE OF LEUBAT (DELTA6 MUTANT) IN COMPLEX WITH DESVENLAFAXINE)

Ligand code = 29J (link to the list of PDB complexes)

Download experimental 3D coordinates of 29J with added hydrogens

MW 263.37
NB_atoms 19
XLogP 2.73
PSA 41.715
NB_HD 2
NB_HA 3
fsp3 0.62
Lipinski(0=no;1=yes) 1

FDA
NDA 021992 (label) INN (DESVENLAFAXINE SUCCINATE) PRISTIQ (PF PRISM CV) APPROVAL= AP YEAR= 2008
NDA 204150 (label) INN (DESVENLAFAXINE) DESVENLAFAXINE (ALEMBIC PHARMS LTD) APPROVAL= AP YEAR= 2013
NDA 204683 (label) INN (DESVENLAFAXINE) KHEDEZLA (OSMOTICA PHARM CORP) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 205208 (label) INN (DESVENLAFAXINE FUMARATE) DESVENLAFAXINE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 205583 (label) INN (DESVENLAFAXINE FUMARATE) DESVENLAFAXINE (SUN PHARM) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 204003 (pdf not found) INN (DESVENLAFAXINE SUCCINATE) DESVENLAFAXINE SUCCINATE (ALEMBIC) APPROVAL= AP YEAR= 2015
NDA 204028 (pdf not found) INN (DESVENLAFAXINE SUCCINATE) DESVENLAFAXINE SUCCINATE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2015
NDA 204095 (pdf not found) INN (DESVENLAFAXINE SUCCINATE) DESVENLAFAXINE SUCCINATE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 204172 (pdf not found) INN (DESVENLAFAXINE SUCCINATE) DESVENLAFAXINE SUCCINATE (LUPIN) APPROVAL= AP YEAR= 2015
NDA 204082 (pdf not found) INN (DESVENLAFAXINE SUCCINATE) DESVENLAFAXINE SUCCINATE (HIKMA) APPROVAL= AP YEAR= 2016 OBSOLETE
NDA 204083 (pdf not found) INN (DESVENLAFAXINE SUCCINATE) DESVENLAFAXINE SUCCINATE (HIKMA) APPROVAL= AP YEAR= 2016
NDA 204009 (pdf not found) INN (DESVENLAFAXINE) DESVENLAFAXINE (ANCHEN PHARMS) APPROVAL= TA YEAR= 2016
NDA 204065 (pdf not found) INN (DESVENLAFAXINE SUCCINATE) DESVENLAFAXINE SUCCINATE (ACTAVIS LABS FL) APPROVAL= AP YEAR= 2016
NDA 204020 (pdf not found) INN (DESVENLAFAXINE SUCCINATE) DESVENLAFAXINE SUCCINATE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 210014 (pdf not found) INN (DESVENLAFAXINE SUCCINATE) DESVENLAFAXINE SUCCINATE (YICHANG HUMANWELL) APPROVAL= AP YEAR= 2018
NDA 204805 (pdf not found) INN (DESVENLAFAXINE SUCCINATE) DESVENLAFAXINE SUCCINATE (PLATINUM) APPROVAL= AP YEAR= 2019
NDA 211427 (pdf not found) INN (DESVENLAFAXINE SUCCINATE) DESVENLAFAXINE SUCCINATE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2025
NDA 220460 (pdf not found) INN (DESVENLAFAXINE SUCCINATE) DESVENLAFAXINE SUCCINATE (YICHANG HUMANWELL) APPROVAL= AP YEAR= 2026