e-Drug3D

1391

GLUTATHIONE DISULFIDE

INN
GLUTATHIONE DISULFIDE

cas 27025-41-8

CLASS

VARIOUS
ANTIDOTE
FOR USE AS AN INTRAOCULAR IRRIGATING SOLUTION DURING INTRAOCULAR SURGICAL PROCEDURES INVOLVING PERFUSION OF THE EYE

ROUTE (list)

IRRIGATION

ATC code

V03AB32

PK parameters

Target

TARGET GLUTATHIONE S-TRANSFERASE MU 2

PDB
4ZB6 (CRYSTAL STRUCTURE OF GLUTATHIONE TRANSFERASE URE2P4 FROM PHANEROCHAETE CHRYSOSPORIUM IN COMPLEX WITH OXIDIZED GLUTATHIONE.)

Ligand code = GDS (link to the list of PDB complexes)

Download experimental 3D coordinates of GDS with added hydrogens

DrugCentral

GLUTATHIONE REDUCTASE CHEMBL2755 GLUTATHIONE REDUCTASE UNIPROT P00390 GLUTATHIONE REDUCTASE, MITOCHONDRIAL HOMO SAPIENS ENZYME REDUCTASE

Download SDF file

Glycine, L-.gamma.-glutamyl-L-cysteinyl-, bimol. (22')-disulfide

Formula:
C20H32N6O12S2

Calculated chemical properties:

MW 608.62
NB_atoms 40
XLogP -9.22
PSA 293.899
NB_HD 8
NB_HA 18
fsp3 0.60
Lipinski(0=no;1=yes) 0

FDA
NDA 018469 (label) INN (CALCIUM CHLORIDE ; DEXTROSE ; GLUTATHIONE DISULFIDE ; MAGNESIUM CHLORIDE ; POTASSIUM CHLORIDE ; SODIUM BICARBONATE ; SODIUM CHLORIDE ; SODIUM PHOSPHATE) BSS PLUS (ALCON) APPROVAL= AP YEAR= 1981
NDA 020079 (pdf not found) INN (CALCIUM CHLORIDE ; DEXTROSE ; GLUTATHIONE DISULFIDE ; MAGNESIUM CHLORIDE ; POTASSIUM CHLORIDE ; SODIUM BICARBONATE ; SODIUM CHLORIDE ; SODIUM PHOSPHATE) METHOTREXATE SODIUM (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 022193 (label) INN (CALCIUM CHLORIDE ; DEXTROSE ; MAGNESIUM CHLORIDE ; OXIGLUTATIONE ; POTASSIUM CHLORIDE ; SODIUM BICARBONATE ; SODIUM CHLORIDE ; SODIUM PHOSPHATE) NAVSTEL (ALCON PHARMS LTD) APPROVAL= AP YEAR= 2008 DISCONTINUED