e-Drug3D

136

cas 59-66-5

CLASS

SENSORY
CARBONIC ANHYDRASE INHIBITOR
ANTIGLAUCOMA
ANTICONVULSANTS
DIURETICS

ROUTE (list)

ORAL INJECTION

PK parameters

F 100 PERCENT
Tmax 4.5 HOUR
VD 13 LITER (65 KILOGRAM)
Cl 1.1 LITER / HOUR (65 KILOGRAM)
PPB 93 PERCENT
t1/2 3.5 HOUR (PMID9650543)

TARGET CARBONIC ANHYDRASE

PDB
1AZM (DRUG-PROTEIN INTERACTIONS: STRUCTURE OF SULFONAMIDE DRUG COMPLEXED WITH HUMAN CARBONIC ANHYDRASE I)

Ligand code = AZM (link to the list of PDB complexes)

Download experimental 3D coordinates of AZM with added hydrogens

MW 222.27
NB_atoms 13
XLogP -0.86
PSA 111.25
NB_HD 3
NB_HA 7
fsp3 0.25
Lipinski(0=no;1=yes) 1

FDA
NDA 084498 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 087686 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (ASCOT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089619 (pdf not found) INN (ACETAZOLAMIDE SODIUM) ACETAZOLAMIDE SODIUM (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 008943 (label) INN (ACETAZOLAMIDE) DIAMOX (TEVA BRANDED PHARM) APPROVAL= AP YEAR= 1953 DISCONTINUED
NDA 009388 (label) INN (ACETAZOLAMIDE SODIUM) DIAMOX (TEVA WOMENS) APPROVAL= AP YEAR= 1954 DISCONTINUED
NDA 012945 (label) INN (ACETAZOLAMIDE) DIAMOX (TEVA BRANDED PHARM) APPROVAL= AP YEAR= 1962 DISCONTINUED
NDA 083320 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (ALRA) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 084840 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 1978
NDA 087654 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (VANGARD) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 088882 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (HERITAGE PHARMA) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 089752 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (MUTUAL PHARM) APPROVAL= AP YEAR= 1988 OBSOLETE
NDA 089753 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 040089 (pdf not found) INN (ACETAZOLAMIDE SODIUM) ACETAZOLAMIDE SODIUM (HIKMA) APPROVAL= AP YEAR= 1995
NDA 040108 (pdf not found) INN (ACETAZOLAMIDE SODIUM) ACETAZOLAMIDE SODIUM (HOSPIRA) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 040195 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (TARO) APPROVAL= AP YEAR= 1997
NDA 040784 (pdf not found) INN (ACETAZOLAMIDE SODIUM) ACETAZOLAMIDE SODIUM (XGEN PHARMS) APPROVAL= AP YEAR= 2008
NDA 040904 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (HERITAGE PHARMA) APPROVAL= AP YEAR= 2008
NDA 090779 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (INDICUS PHARMA) APPROVAL= AP YEAR= 2011
NDA 200880 (pdf not found) INN (ACETAZOLAMIDE SODIUM) ACETAZOLAMIDE SODIUM (MYLAN ASI) APPROVAL= AP YEAR= 2012
NDA 202693 (pdf not found) INN (ACETAZOLAMIDE SODIUM) ACETAZOLAMIDE SODIUM (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2014
NDA 204691 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (MPP PHARMA) APPROVAL= AP YEAR= 2016
NDA 203434 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (NOVAST LABS) APPROVAL= AP YEAR= 2016
NDA 205530 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (HERITAGE PHARMA) APPROVAL= AP YEAR= 2016
NDA 205358 (label) INN (ACETAZOLAMIDE SODIUM) ACETAZOLAMIDE SODIUM (PH HEALTH) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 209734 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 2017
NDA 207659 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2018
NDA 205301 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (CADILA) APPROVAL= AP YEAR= 2019
NDA 206533 (pdf not found) INN (ACETAZOLAMIDE SODIUM) ACETAZOLAMIDE SODIUM (ZYDUS PHARMS) APPROVAL= AP YEAR= 2019
NDA 210423 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (ALEMBIC) APPROVAL= AP YEAR= 2019
NDA 203917 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (RISING) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 210588 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2019
NDA 211556 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (HIBROW HLTHCARE) APPROVAL= AP YEAR= 2019
NDA 207503 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (BRECKENRIDGE) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 207401 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (MICRO LABS LTD INDIA) APPROVAL= AP YEAR= 2020
NDA 214282 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (MANKIND PHARMA) APPROVAL= AP YEAR= 2020
NDA 211372 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2021
NDA 215101 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2021
NDA 211069 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2023
NDA 217197 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (NE RX PHARMA) APPROVAL= AP YEAR= 2023
NDA 211151 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 213706 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (TORRENT) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 218023 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2024
NDA 212089 (pdf not found) INN (ACETAZOLAMIDE) ACETAZOLAMIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2025
NDA 219775 (pdf not found) INN (ACETAZOLAMIDE SODIUM) ACETAZOLAMIDE SODIUM (GLAND) APPROVAL= AP YEAR= 2025