e-Drug3D

1322

cas 474-86-2

CLASS

HORMONES
ESTROGENIC
A BLEND OF SYNTHETIC ESTROGENIC SUBSTANCES
EQUILIN IS ONE EXAMPLE

ROUTE (list)

ORAL INJECTION TOPICAL VAGINAL

PK parameters

Tmax 5 HOUR
Cmax 0.15 NANOMOLAR
t1/2 15 HOUR

TARGET ESTROGEN RECEPTOR (ER)
ESTRADIOL 17-BETA-DEHYDROGENASE 1

PDB
1EQU (TYPE 1 17-BETA HYDROXYSTEROID DEHYDROGENASE EQUILIN COMPLEXED WITH NADP+)

Ligand code = EQI (link to the list of PDB complexes)

Download experimental 3D coordinates of EQI with added hydrogens

MW 268.34
NB_atoms 20
XLogP 3.74
PSA 38.924
NB_HD 1
NB_HA 2
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 083209 (pdf not found) INN (ESTROGENS) ESTRATAB (SOLVAY) APPROVAL= AP YEAR= 0
NDA 083266 (pdf not found) INN (ESTROGENS) AMNESTROGEN (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 0
NDA 083376 (pdf not found) INN (ESTROGENS) EVEX (ROCHE PALO) APPROVAL= AP YEAR= 0
NDA 083414 (pdf not found) INN (ESTROGENS) ESTERIFIED ESTROGENS (PVT FORM) APPROVAL= AP YEAR= 0
NDA 083765 (pdf not found) INN (ESTROGENS) ESTERIFIED ESTROGENS (PVT FORM) APPROVAL= AP YEAR= 0
NDA 083856 (pdf not found) INN (ESTROGENS) ESTRATAB (SOLVAY) APPROVAL= AP YEAR= 0
NDA 083857 (pdf not found) INN (ESTROGENS) ESTRATAB (SOLVAY) APPROVAL= AP YEAR= 0
NDA 084215 (pdf not found) INN (ESTROGENS) EVEX (ROCHE PALO) APPROVAL= AP YEAR= 0
NDA 085007 (pdf not found) INN (ESTROGENS) FEMOGEN (PVT FORM) APPROVAL= AP YEAR= 0
NDA 085076 (pdf not found) INN (ESTROGENS) FEMOGEN (PVT FORM) APPROVAL= AP YEAR= 0
NDA 085302 (pdf not found) INN (ESTROGENS) ESTERIFIED ESTROGENS (SANDOZ) APPROVAL= AP YEAR= 0
NDA 085907 (pdf not found) INN (ESTROGENS) ESTERIFIED ESTROGENS (PVT FORM) APPROVAL= AP YEAR= 0
NDA 086715 (pdf not found) INN (ESTROGENS) ESTRATAB (SOLVAY) APPROVAL= AP YEAR= 0
NDA 004782 (label) INN (ESTROGENS) PREMARIN (WYETH PHARMS) APPROVAL= AP YEAR= 1942 NEWMOLECULARENTITY
NDA 010402 (label) INN (ESTROGENS) PREMARIN (WYETH PHARMS) APPROVAL= AP YEAR= 1956
NDA 084948 (pdf not found) INN (ESTROGENS) MENEST (MONARCH PHARMS) APPROVAL= AP YEAR= 1977
NDA 084949 (pdf not found) INN (ESTROGENS) MENEST (MONARCH PHARMS) APPROVAL= AP YEAR= 1977
NDA 084950 (pdf not found) INN (ESTROGENS) MENEST (MONARCH PHARMS) APPROVAL= AP YEAR= 1977
NDA 084951 (pdf not found) INN (ESTROGENS) MENEST (MONARCH PHARMS) APPROVAL= AP YEAR= 1977
NDA 020216 (label) INN (ESTROGENS) PREMARIN (WYETH PHARMS) APPROVAL= AP YEAR= 1978
NDA 085008 (pdf not found) INN (ESTROGENS) FEMOGEN (PVT FORM) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 020992 (label) INN (ESTROGENS) CENESTIN (DURAMED) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 021417 (label) INN (ESTROGENS) PREMARIN (WYETH PHARMS) APPROVAL= AP YEAR= 2003
NDA 021443 (label) INN (ESTROGENS) ENJUVIA (DURAMED) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 021609 (label) INN (ESTROGENS) ENJUVIA (DURAMED) APPROVAL= AP YEAR= 2004 DISCONTINUED