e-Drug3D
1287
ROSIGLITAZONE
INN
ROSIGLITAZONE
cas 122320-73-4
CLASS
FIBRINOLYTIC AGENTS
HYPOGLYCEMIC AGENTS
THAZOLIDINEDIONES
INSULIN SENSITIZER
VASODILATOR AGENTS
ANTIDIABETIC
ROUTE (list)
ORAL
PK parameters
F 99 PERCENT
VD 17.6 LITER
Cl 3.03 LITER / HOUR
PPB 99.8 PERCENT
t1/2 3.5 HOUR
Solubility
SOLUBLE IN A BUFFERED AQUEOUS SOLUTION WITH PH 5 OF 2.3 BUT DECREASES WITH INCREASING PH
TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
PDB
1ZGY (STRUCTURAL AND BIOCHEMICAL BASIS FOR SELECTIVE REPRESSION OF THE ORPHAN NUCLEAR RECEPTOR LRH-1 BY SHP)
Ligand code = BRL (link to the list of PDB complexes)
Download experimental 3D coordinates of BRL with added hydrogens
Peroxisome proliferator-activated receptor gamma UNIPROT P37231 PPARG
Formula:
C18H19N3O3S
Calculated chemical properties:
MW 357.43
NB_atoms 25
XLogP 2.49
PSA 71.149
NB_HD 1
NB_HA 6
fsp3 0.28
Lipinski(0=no;1=yes) 1
NB_atoms 25
XLogP 2.49
PSA 71.149
NB_HD 1
NB_HA 6
fsp3 0.28
Lipinski(0=no;1=yes) 1
FDA
NDA 021071 (label) INN (ROSIGLITAZONE MALEATE) AVANDIA (WOODWARD) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 021410 (label) INN (METFORMIN HYDROCHLORIDE ; ROSIGLITAZONE MALEATE) AVANDAMET (SB PHARMCO) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021700 (label) INN (GLIMEPIRIDE ; ROSIGLITAZONE MALEATE) AVANDARYL (SB PHARMCO) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 078023 (pdf not found) INN (ROSIGLITAZONE MALEATE) ROSIGLITAZONE (WATSON LABS) APPROVAL= TA YEAR= 2007
NDA 078695 (pdf not found) INN (ROSIGLITAZONE MALEATE) ROSIGLITAZONE MALEATE (ROXANE) APPROVAL= TA YEAR= 2008
NDA 078825 (pdf not found) INN (ROSIGLITAZONE MALEATE) ROSIGLITAZONE MALEATE (MYLAN PHARMA) APPROVAL= TA YEAR= 2008
NDA 078658 (pdf not found) INN (ROSIGLITAZONE MALEATE) ROSIGLITAZONE MALEATE (HIKMA PHARMS) APPROVAL= TA YEAR= 2009
NDA 078674 (pdf not found) INN (ROSIGLITAZONE MALEATE) ROSIGLITAZONE MALEATE (SANDOZ) APPROVAL= TA YEAR= 2009
NDA 076747 (label) INN (ROSIGLITAZONE MALEATE) ROSIGLITAZONE MALEATE (ANI PHARMS) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 077337 (label) INN (METFORMIN HYDROCHLORIDE ; ROSIGLITAZONE MALEATE) ROSIGLITAZONE MALEATE AND METFORMIN HYDROCHLORIDE (TEVA) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 076748 (pdf not found) INN (ROSIGLITAZONE MALEATE) ROSIGLITAZONE (DR REDDYS LABS INC) APPROVAL= TA YEAR= 2016
NDA 078709 (label) INN (GLIMEPIRIDE ; ROSIGLITAZONE MALEATE) ROSIGLITAZONE MALEATE AND GLIMEPIRIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 021071 (label) INN (ROSIGLITAZONE MALEATE) AVANDIA (WOODWARD) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 021410 (label) INN (METFORMIN HYDROCHLORIDE ; ROSIGLITAZONE MALEATE) AVANDAMET (SB PHARMCO) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021700 (label) INN (GLIMEPIRIDE ; ROSIGLITAZONE MALEATE) AVANDARYL (SB PHARMCO) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 078023 (pdf not found) INN (ROSIGLITAZONE MALEATE) ROSIGLITAZONE (WATSON LABS) APPROVAL= TA YEAR= 2007
NDA 078695 (pdf not found) INN (ROSIGLITAZONE MALEATE) ROSIGLITAZONE MALEATE (ROXANE) APPROVAL= TA YEAR= 2008
NDA 078825 (pdf not found) INN (ROSIGLITAZONE MALEATE) ROSIGLITAZONE MALEATE (MYLAN PHARMA) APPROVAL= TA YEAR= 2008
NDA 078658 (pdf not found) INN (ROSIGLITAZONE MALEATE) ROSIGLITAZONE MALEATE (HIKMA PHARMS) APPROVAL= TA YEAR= 2009
NDA 078674 (pdf not found) INN (ROSIGLITAZONE MALEATE) ROSIGLITAZONE MALEATE (SANDOZ) APPROVAL= TA YEAR= 2009
NDA 076747 (label) INN (ROSIGLITAZONE MALEATE) ROSIGLITAZONE MALEATE (ANI PHARMS) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 077337 (label) INN (METFORMIN HYDROCHLORIDE ; ROSIGLITAZONE MALEATE) ROSIGLITAZONE MALEATE AND METFORMIN HYDROCHLORIDE (TEVA) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 076748 (pdf not found) INN (ROSIGLITAZONE MALEATE) ROSIGLITAZONE (DR REDDYS LABS INC) APPROVAL= TA YEAR= 2016
NDA 078709 (label) INN (GLIMEPIRIDE ; ROSIGLITAZONE MALEATE) ROSIGLITAZONE MALEATE AND GLIMEPIRIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2016 DISCONTINUED