e-Drug3D
1281
RIZATRIPTAN
INN
RIZATRIPTAN
cas 144034-80-0
CLASS
NERVOUS SYSTEM
ANTIMIGRAINE
SEROTONIN AGONISTS
VASOCONSTRICTOR AGENTS
ROUTE (list)
ORAL
ATC code
N02CC04
PK parameters
F 45 PERCENT
VD 125 LITER
Cl 34.6 LITER / HOUR (EQN)
PPB 14 PERCENT
t1/2 2.5 HOUR
Solubility
SOLUBLE IN WATER AT ABOUT 42 MILLIGRAM / MILLILITER
TARGET 5-HYDROXYTRYPTAMINE 1D RECEPTOR
5-HYDROXYTRYPTAMINE 1B
MONOAMINE OXIDASE TYPE A (MAO-A)
5-hydroxytryptamine receptor 1B UNIPROT P28222 HTR1B
5-hydroxytryptamine receptor 1D UNIPROT P28221 HTR1D
Formula:
C15H19N5
Calculated chemical properties:
MW 269.35
NB_atoms 20
XLogP 1.91
PSA 47.086
NB_HD 1
NB_HA 5
fsp3 0.33
Lipinski(0=no;1=yes) 1
NB_atoms 20
XLogP 1.91
PSA 47.086
NB_HD 1
NB_HA 5
fsp3 0.33
Lipinski(0=no;1=yes) 1
FDA
NDA 020864 (label) INN (RIZATRIPTAN BENZOATE) MAXALT (ORGANON LLC) APPROVAL= AP YEAR= 1998
NDA 020865 (label) INN (RIZATRIPTAN BENZOATE) MAXALT-MLT (ORGANON) APPROVAL= AP YEAR= 1998
NDA 077263 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (TEVA PHARMS) APPROVAL= AP YEAR= 2012
NDA 078173 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 079230 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (SANDOZ) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 200482 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (NATCO PHARMA LTD) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 201967 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 201993 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202047 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (CREEKWOOD PHARMS) APPROVAL= AP YEAR= 2012
NDA 202244 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (APOTEX INC) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202490 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2012
NDA 078739 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (CHARTWELL RX) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 077526 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (CHARTWELL RX) APPROVAL= AP YEAR= 2013
NDA 201914 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 202477 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (APOTEX INC) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 203062 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2013
NDA 203478 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (NATCO PHARMA LTD) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 204090 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 204339 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (INVAGEN PHARMS) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 203146 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2014
NDA 203147 (label) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2014
NDA 203252 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (JUBILANT GENERICS) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 203334 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (JUBILANT GENERICS) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 203269 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2016
NDA 204722 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (PANACEA) APPROVAL= AP YEAR= 2017
NDA 207835 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (UNICHEM) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 207836 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (UNICHEM) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 205394 (label) INN (RIZATRIPTAN BENZOATE) RIZAFILM (GENSCO) APPROVAL= AP YEAR= 2023
NDA 215431 (label) INN (MELOXICAM ; RIZATRIPTAN BENZOATE) SYMBRAVO (AXSOME) APPROVAL= AP YEAR= 2025
NDA 020864 (label) INN (RIZATRIPTAN BENZOATE) MAXALT (ORGANON LLC) APPROVAL= AP YEAR= 1998
NDA 020865 (label) INN (RIZATRIPTAN BENZOATE) MAXALT-MLT (ORGANON) APPROVAL= AP YEAR= 1998
NDA 077263 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (TEVA PHARMS) APPROVAL= AP YEAR= 2012
NDA 078173 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 079230 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (SANDOZ) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 200482 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (NATCO PHARMA LTD) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 201967 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 201993 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202047 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (CREEKWOOD PHARMS) APPROVAL= AP YEAR= 2012
NDA 202244 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (APOTEX INC) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202490 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2012
NDA 078739 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (CHARTWELL RX) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 077526 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (CHARTWELL RX) APPROVAL= AP YEAR= 2013
NDA 201914 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 202477 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (APOTEX INC) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 203062 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2013
NDA 203478 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (NATCO PHARMA LTD) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 204090 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 204339 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (INVAGEN PHARMS) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 203146 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2014
NDA 203147 (label) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2014
NDA 203252 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (JUBILANT GENERICS) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 203334 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (JUBILANT GENERICS) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 203269 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2016
NDA 204722 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (PANACEA) APPROVAL= AP YEAR= 2017
NDA 207835 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (UNICHEM) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 207836 (pdf not found) INN (RIZATRIPTAN BENZOATE) RIZATRIPTAN BENZOATE (UNICHEM) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 205394 (label) INN (RIZATRIPTAN BENZOATE) RIZAFILM (GENSCO) APPROVAL= AP YEAR= 2023
NDA 215431 (label) INN (MELOXICAM ; RIZATRIPTAN BENZOATE) SYMBRAVO (AXSOME) APPROVAL= AP YEAR= 2025