e-Drug3D

1279

cas 128196-01-0

CLASS

NERVOUS SYSTEM
ANTIDEPRESSANT
SEROTONIN REUPTAKE INHIBITOR (SSRI)

ROUTE (list)

ORAL

PK parameters

F 80 PERCENT
VD 780 LITER (65 KILOGRAM)
Cl 36 LITER / HOUR
PPB 56 PERCENT
t1/2 29.5 HOUR

TARGET SEROTONIN TRANSPORTER

PDB
5I75 (X-RAY STRUCTURE OF THE TS3 HUMAN SEROTONIN TRANSPORTER COMPLEXED WITH S-CITALOPRAM AT THE CENTRAL SITE AND BR-CITALOPRAM AT THE ALLOSTERIC SITE)

Ligand code = 68P (link to the list of PDB complexes)

Download experimental 3D coordinates of 68P with added hydrogens

MW 324.39
NB_atoms 24
XLogP 3.81
PSA 33.82
NB_HD 0
NB_HA 3
fsp3 0.35
Lipinski(0=no;1=yes) 1

FDA
NDA 021323 (label) INN (ESCITALOPRAM OXALATE) LEXAPRO (ABBVIE) APPROVAL= AP YEAR= 2002
NDA 021365 (label) INN (ESCITALOPRAM OXALATE) LEXAPRO (ABBVIE) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021440 (label) INN (ESCITALOPRAM OXALATE) LEXAPRO (FOREST LABS) APPROVAL= AP YEAR= 2002 NEWAPPLICATION
NDA 076981 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM (ALPHAPHARM) APPROVAL= TA YEAR= 2006
NDA 077412 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (TEVA PHARMS) APPROVAL= TA YEAR= 2006
NDA 077660 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (RISING) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077798 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (DR REDDYS LABS INC) APPROVAL= TA YEAR= 2007
NDA 078219 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (CARACO) APPROVAL= TA YEAR= 2007
NDA 078467 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (SANDOZ) APPROVAL= TA YEAR= 2007
NDA 078313 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (WATSON LABS) APPROVAL= TA YEAR= 2008
NDA 076765 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 077512 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (AIPING PHARM INC) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 077734 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2012
NDA 078169 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (CHARTWELL RX) APPROVAL= AP YEAR= 2012
NDA 078604 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (INVAGEN PHARMS) APPROVAL= AP YEAR= 2012
NDA 078777 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (GRAVITI PHARMS) APPROVAL= AP YEAR= 2012
NDA 079062 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2012
NDA 090432 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2012
NDA 090939 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (TORRENT PHARMS LTD) APPROVAL= AP YEAR= 2012
NDA 202227 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2012
NDA 078766 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (HIKMA PHARMS) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 079121 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (SUN PHARMA CANADA) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202210 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2012
NDA 202221 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (HETERO LABS LTD III) APPROVAL= AP YEAR= 2012
NDA 202280 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (JUBILANT CADISTA) APPROVAL= AP YEAR= 2012
NDA 202389 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2012
NDA 090477 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2013
NDA 077550 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 078032 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (PRINSTON INC) APPROVAL= AP YEAR= 2015
NDA 203967 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (ANTRIM PHARMS LLC) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 202754 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2016
NDA 205619 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2017
NDA 215177 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (ASCENT PHARMS INC) APPROVAL= AP YEAR= 2025
NDA 219130 (label) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM (ALMATICA) APPROVAL= AP YEAR= 2025
NDA 091655 (pdf not found) INN (ESCITALOPRAM OXALATE) ESCITALOPRAM OXALATE (MICRO LABS) APPROVAL= AP YEAR= 2026