e-Drug3D

1252

GOSERELIN

INN
GOSERELIN

cas 65807-02-5

CLASS

ANTINEOPLASTIC
PROSTATE CANCER (THERAPEUTIC)
GONADOTROPIN RELEASING HORMONE (GNRH) AGONIST
INHIBITS PITUITARY GONADOTROPIN SECRETION

ROUTE (list)

IMPLANTATION

ATC code

L02AE03

PK parameters

Cmax 2.23 NANOMOLAR
VD 20.3 LITER
Cl 9.78 LITER / HOUR
PPB 27.3 PERCENT
t1/2 1.4 HOUR (EQN)

Solubility

SOLUBLE IN WATER

Target

TARGET GONADOTROPIN-RELEASING HORMONE RECEPTOR

DrugCentral

Gonadotropin-releasing hormone receptor UNIPROT P30968 GNRHR

Download SDF file

N-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

Formula:
C59H84N18O14

Calculated chemical properties:

MW 1270.45
NB_atoms 91
XLogP -4.72
PSA 457.333
NB_HD 21
NB_HA 31
fsp3 0.51
Lipinski(0=no;1=yes) 0

FDA
NDA 019726 (label) INN (GOSERELIN ACETATE) ZOLADEX (TERSERA) APPROVAL= AP YEAR= 1989
NDA 020515 (label) INN (GOSERELIN) ZOLADEX (TERSERA) APPROVAL= AP YEAR= 1995 NEWAPPLICATION
NDA 020578 (label) INN (GOSERELIN ACETATE) ZOLADEX (TERSERA) APPROVAL= AP YEAR= 1996