e-Drug3D

1246

cas 100-33-4

CLASS

ANTIPARASITIC
ANTIPROTOZOAL AGENTS
TRYPANOCIDAL AGENTS
INTERFERES WITH MICROBIAL NUCLEAR 5 METABOLISM BY INHIBITION OF DNA, RNA, PHOSPHOLIPID AND PROTEIN SYNTHESIS
ACTIVE AGAINST PNEUMOCYSTIS JIROVECI (PJP)
GROUP I INTRON SPLICE INHIBITOR
ANTIMALARIALS

ROUTE (list)

INJECTION INHALATION

PK parameters

VD 3445 LITER (65 KILOGRAM)
Cl 248 LITER / HOUR
t1/2 25 HOUR

TARGET DNA-BINDING
PROTEIN S100-B
TRANSCRIPTIONAL REGULATOR QACR

PDB
1RKW (CRYSTAL STRUCTURE OF THE MULTIDRUG BINDING TRANSCRIPTIONAL REPRESSOR QACR BOUND TO PENTAMADINE)

Ligand code = PNT (link to the list of PDB complexes)

Download experimental 3D coordinates of PNT with added hydrogens

MW 342.44
NB_atoms 25
XLogP -0.76
PSA 113.888
NB_HD 8
NB_HA 4
fsp3 0.26
Lipinski(0=no;1=yes) 0

FDA
NDA 073447 (pdf not found) INN (PENTAMIDINE ISETHIONATE) PENTACARINAT (ARMOUR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 019264 (pdf not found) INN (PENTAMIDINE ISETHIONATE) PENTAM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1984
NDA 019887 (label) INN (PENTAMIDINE ISETHIONATE) NEBUPENT (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1989
NDA 073479 (pdf not found) INN (PENTAMIDINE ISETHIONATE) PENTAMIDINE ISETHIONATE (HOSPIRA) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 073617 (pdf not found) INN (PENTAMIDINE ISETHIONATE) PENTAMIDINE ISETHIONATE (BAXTER HLTHCARE) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074303 (pdf not found) INN (PENTAMIDINE ISETHIONATE) PENTAMIDINE ISETHIONATE (WATSON LABS) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 206666 (pdf not found) INN (PENTAMIDINE ISETHIONATE) PENTAMIDINE ISETHIONATE (PAI HOLDINGS) APPROVAL= AP YEAR= 2017
NDA 206667 (pdf not found) INN (PENTAMIDINE ISETHIONATE) PENTAMIDINE ISETHIONATE (PAI HOLDINGS) APPROVAL= AP YEAR= 2019
NDA 213806 (pdf not found) INN (PENTAMIDINE ISETHIONATE) PENTAMIDINE ISETHIONATE (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2021
NDA 206982 (pdf not found) INN (PENTAMIDINE ISETHIONATE) PENTAMIDINE ISETHIONATE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 206983 (pdf not found) INN (PENTAMIDINE ISETHIONATE) PENTAMIDINE ISETHIONATE (X-GEN PHARMS INC) APPROVAL= AP YEAR= 2023