e-Drug3D
1237
NICOTINE
INN
NICOTINE
cas 54-11-5
CLASS
NERVOUS SYSTEM
CNS STIMULANT
ANTI-CRAVING AGENTS
AUTONOMIC DRUGS
GANGLIONIC STIMULANTS
NICOTINIC CHOLINERGIC RECEPTOR AGONISTS
ROUTE (list)
BUCCAL TRANSDERMAL NASAL ORAL
ATC code
N07BA01
PK parameters
F 53 PERCENT (INHALATED)
VD 162 LITER (65 KILOGRAM)
Cl 72 LITER / HOUR
PPB 5 PERCENT
t1/2 1.5 HOUR
Solubility
SOLUBLE
TARGET ACETYLCHOLINE RECEPTOR
PDB
5KXI (X-RAY STRUCTURE OF THE HUMAN ALPHA4BETA2 NICOTINIC RECEPTOR)
Ligand code = NCT (link to the list of PDB complexes)
Download experimental 3D coordinates of NCT with added hydrogens
Neuronal acetylcholine receptor
Formula:
C10H14N2
Calculated chemical properties:
MW 162.23
NB_atoms 12
XLogP 1.85
PSA 15.596
NB_HD 0
NB_HA 2
fsp3 0.50
Lipinski(0=no;1=yes) 1
NB_atoms 12
XLogP 1.85
PSA 15.596
NB_HD 0
NB_HA 2
fsp3 0.50
Lipinski(0=no;1=yes) 1
FDA
NDA 018612 (label) INN (NICOTINE POLACRILEX) NICORETTE (HALEON US HOLDINGS) APPROVAL= AP YEAR= 1984
NDA 020076 (label) INN (NICOTINE) HABITROL (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1991
NDA 020165 (label) INN (NICOTINE) NICODERM CQ (CHATTEM SANOFI) APPROVAL= AP YEAR= 1991
NDA 019983 (label) INN (NICOTINE) PROSTEP (AVEVA) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 020066 (label) INN (NICOTINE POLACRILEX) NICORETTE (HALEON US HOLDINGS) APPROVAL= AP YEAR= 1992
NDA 020385 (label) INN (NICOTINE) NICOTROL (PFIZER INC) APPROVAL= AP YEAR= 1996
NDA 020536 (pdf not found) INN (NICOTINE) NICOTROL (MCNEIL CONS) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 020714 (label) INN (NICOTINE) NICOTROL (PFIZER) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074611 (pdf not found) INN (NICOTINE) NICOTINE (AVEVA) APPROVAL= AP YEAR= 1997 OBSOLETE
NDA 074612 (pdf not found) INN (NICOTINE) NICOTINE (DIFGEN PHARMS) APPROVAL= AP YEAR= 1997
NDA 074645 (pdf not found) INN (NICOTINE) NICOTINE (AVEVA) APPROVAL= AP YEAR= 1997 OBSOLETE
NDA 074507 (label) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 1999
NDA 074707 (label) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 1999
NDA 021330 (label) INN (NICOTINE POLACRILEX) NICORETTE (HALEON US HOLDINGS) APPROVAL= AP YEAR= 2002
NDA 076568 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2004
NDA 076569 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2004
NDA 076775 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (L PERRIGO CO) APPROVAL= AP YEAR= 2004
NDA 076776 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (L PERRIGO CO) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076777 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (L PERRIGO CO) APPROVAL= AP YEAR= 2004
NDA 076778 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (L PERRIGO CO) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076779 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (L PERRIGO CO) APPROVAL= AP YEAR= 2004
NDA 076789 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (L PERRIGO CO) APPROVAL= AP YEAR= 2004
NDA 077007 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2006
NDA 078325 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2006
NDA 078326 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2006
NDA 077656 (pdf not found) INN (NICOTINE POLACRILEX) THRIVE (GLAXOSMITHKLINE CONS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077658 (pdf not found) INN (NICOTINE POLACRILEX) THRIVE (GLAXOSMITHKLINE CONS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078546 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2007
NDA 078547 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2007
NDA 078967 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078968 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078697 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2008
NDA 078699 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2008
NDA 022360 (label) INN (NICOTINE POLACRILEX) NICORETTE (HALEON US HOLDINGS) APPROVAL= AP YEAR= 2009
NDA 076880 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 077850 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 079038 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2009
NDA 079044 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2009
NDA 079216 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2009
NDA 079219 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2009
NDA 090711 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PPI-DAC) APPROVAL= AP YEAR= 2009
NDA 090821 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2009
NDA 091349 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2011
NDA 091354 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2011
NDA 203690 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PPI-DAC) APPROVAL= AP YEAR= 2012
NDA 204794 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2016
NDA 204833 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2016
NDA 206393 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2016
NDA 206394 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2016
NDA 209206 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2018
NDA 209519 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2018
NDA 208875 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2019
NDA 207868 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PLD ACQUISITIONS) APPROVAL= AP YEAR= 2019
NDA 209520 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2019
NDA 210711 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2019
NDA 210712 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2019
NDA 212056 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2019
NDA 212057 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2020
NDA 212796 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2020
NDA 212983 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2020
NDA 213233 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2020
NDA 213266 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2021
NDA 215357 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2022
NDA 214354 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (FERTIN PHARMA) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 215276 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2025
NDA 018612 (label) INN (NICOTINE POLACRILEX) NICORETTE (HALEON US HOLDINGS) APPROVAL= AP YEAR= 1984
NDA 020076 (label) INN (NICOTINE) HABITROL (DR REDDYS LABS SA) APPROVAL= AP YEAR= 1991
NDA 020165 (label) INN (NICOTINE) NICODERM CQ (CHATTEM SANOFI) APPROVAL= AP YEAR= 1991
NDA 019983 (label) INN (NICOTINE) PROSTEP (AVEVA) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 020066 (label) INN (NICOTINE POLACRILEX) NICORETTE (HALEON US HOLDINGS) APPROVAL= AP YEAR= 1992
NDA 020385 (label) INN (NICOTINE) NICOTROL (PFIZER INC) APPROVAL= AP YEAR= 1996
NDA 020536 (pdf not found) INN (NICOTINE) NICOTROL (MCNEIL CONS) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 020714 (label) INN (NICOTINE) NICOTROL (PFIZER) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074611 (pdf not found) INN (NICOTINE) NICOTINE (AVEVA) APPROVAL= AP YEAR= 1997 OBSOLETE
NDA 074612 (pdf not found) INN (NICOTINE) NICOTINE (DIFGEN PHARMS) APPROVAL= AP YEAR= 1997
NDA 074645 (pdf not found) INN (NICOTINE) NICOTINE (AVEVA) APPROVAL= AP YEAR= 1997 OBSOLETE
NDA 074507 (label) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 1999
NDA 074707 (label) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 1999
NDA 021330 (label) INN (NICOTINE POLACRILEX) NICORETTE (HALEON US HOLDINGS) APPROVAL= AP YEAR= 2002
NDA 076568 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2004
NDA 076569 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2004
NDA 076775 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (L PERRIGO CO) APPROVAL= AP YEAR= 2004
NDA 076776 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (L PERRIGO CO) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076777 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (L PERRIGO CO) APPROVAL= AP YEAR= 2004
NDA 076778 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (L PERRIGO CO) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076779 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (L PERRIGO CO) APPROVAL= AP YEAR= 2004
NDA 076789 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (L PERRIGO CO) APPROVAL= AP YEAR= 2004
NDA 077007 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2006
NDA 078325 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2006
NDA 078326 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2006
NDA 077656 (pdf not found) INN (NICOTINE POLACRILEX) THRIVE (GLAXOSMITHKLINE CONS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077658 (pdf not found) INN (NICOTINE POLACRILEX) THRIVE (GLAXOSMITHKLINE CONS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078546 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2007
NDA 078547 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2007
NDA 078967 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078968 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078697 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2008
NDA 078699 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2008
NDA 022360 (label) INN (NICOTINE POLACRILEX) NICORETTE (HALEON US HOLDINGS) APPROVAL= AP YEAR= 2009
NDA 076880 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 077850 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 079038 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2009
NDA 079044 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2009
NDA 079216 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2009
NDA 079219 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2009
NDA 090711 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PPI-DAC) APPROVAL= AP YEAR= 2009
NDA 090821 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2009
NDA 091349 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2011
NDA 091354 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2011
NDA 203690 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PPI-DAC) APPROVAL= AP YEAR= 2012
NDA 204794 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2016
NDA 204833 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2016
NDA 206393 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2016
NDA 206394 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PERRIGO R AND D) APPROVAL= AP YEAR= 2016
NDA 209206 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2018
NDA 209519 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2018
NDA 208875 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2019
NDA 207868 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (PLD ACQUISITIONS) APPROVAL= AP YEAR= 2019
NDA 209520 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2019
NDA 210711 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2019
NDA 210712 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2019
NDA 212056 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2019
NDA 212057 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (P AND L) APPROVAL= AP YEAR= 2020
NDA 212796 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2020
NDA 212983 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2020
NDA 213233 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2020
NDA 213266 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2021
NDA 215357 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2022
NDA 214354 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (FERTIN PHARMA) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 215276 (pdf not found) INN (NICOTINE POLACRILEX) NICOTINE POLACRILEX (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2025