e-Drug3D

1236

MORPHINE


INN
MORPHINE

cas 57-27-2
CLASS

NERVOUS SYSTEM
ANALGESIC
NARCOTICS
OPIATE
OPIOID RECEPTOR AGONISTS

ROUTE (list)

INJECTION ORAL INTRAMUSCULAR EPIDURAL INTRAVENOUS

NATURAL MOLECULE (link)

ATC code

N02AA01
N02AG01
A07DA52
N02AA51

PK parameters

F 40 PERCENT
Cmax 273 NANOMOLAR
VD 227 LITER (65 KILOGRAM)
Cl 97.5 LITER / HOUR (65 KILOGRAM)
PPB 27 PERCENT
t1/2 2 HOUR

Solubility

SOLUBLE IN WATER


Target

TARGET MU-TYPE OPIOID RECEPTOR

PDB
1Q0Y (ANTI-MORPHINE ANTIBODY 9B1 COMPLEXED WITH MORPHINE)

Ligand code = MOI (link to the list of PDB complexes)

Download experimental 3D coordinates of MOI with added hydrogens

DrugCentral

Mu-type opioid receptor UNIPROT P35372 OPRM1

Download SDF file (5alpha,6alpha)-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol

Formula:
C17H19NO3

Calculated chemical properties:

MW 285.33
NB_atoms 21
XLogP 1.20
PSA 54.52
NB_HD 2
NB_HA 4
fsp3 0.53
Lipinski(0=no;1=yes) 1

FDA
NDA 018565 (label) INN (MORPHINE SULFATE) DURAMORPH PF (HIKMA) APPROVAL= AP YEAR= 1984
NDA 071050 (pdf not found) INN (MORPHINE SULFATE) ASTRAMORPH PF (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 071051 (pdf not found) INN (MORPHINE SULFATE) ASTRAMORPH PF (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 071052 (pdf not found) INN (MORPHINE SULFATE) ASTRAMORPH PF (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 071053 (pdf not found) INN (MORPHINE SULFATE) ASTRAMORPH PF (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 019516 (label) INN (MORPHINE SULFATE) MS CONTIN (KNOA PHARMA) APPROVAL= AP YEAR= 1987
NDA 071849 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (HOSPIRA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071850 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (HOSPIRA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 019999 (label) INN (MORPHINE SULFATE) MORPHINE SULFATE AUTOINJECTOR (MERIDIAN MEDCL TECHN) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 019977 (pdf not found) INN (MORPHINE SULFATE) ORAMORPH SR (XANODYNE PHARMS INC) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073373 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (WATSON LABS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073374 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (WATSON LABS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073375 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (WATSON LABS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073376 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (WATSON LABS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 019916 (label) INN (MORPHINE SULFATE) MORPHINE SULFATE (ICU MEDICAL INC) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 019917 (label) INN (MORPHINE SULFATE) MORPHINE SULFATE (ICU MEDICAL INC) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 073509 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (HOSPIRA) APPROVAL= AP YEAR= 1992
NDA 073510 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (HOSPIRA) APPROVAL= AP YEAR= 1992
NDA 020616 (label) INN (MORPHINE SULFATE) KADIAN (ALLERGAN) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 020631 (label) INN (MORPHINE SULFATE) MORPHINE SULFATE (SPECGX LLC) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074769 (label) INN (MORPHINE SULFATE) MORPHINE SULFATE (RHODES PHARMS) APPROVAL= AP YEAR= 1998
NDA 074862 (label) INN (MORPHINE SULFATE) MORPHINE SULFATE (RHODES PHARMS) APPROVAL= AP YEAR= 1998
NDA 075295 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (STRIDES PHARMA INTL) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 075407 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (DAVA PHARMS INC) APPROVAL= AP YEAR= 2000
NDA 075656 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (WATSON LABS) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 021260 (label) INN (MORPHINE SULFATE) AVINZA (KING PHARMS LLC) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076412 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (SPECGX LLC) APPROVAL= AP YEAR= 2003
NDA 076438 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (SPECGX LLC) APPROVAL= AP YEAR= 2003
NDA 021671 (label) INN (MORPHINE SULFATE) DEPODUR (PACIRA PHARMS INC) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076720 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (NESHER PHARMS) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076733 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (NESHER PHARMS) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 077855 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (NESHER PHARMS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 022195 (label) INN (MORPHINE SULFATE) MORPHINE SULFATE (HIKMA) APPROVAL= AP YEAR= 2008
NDA 022207 (label) INN (MORPHINE SULFATE) MORPHINE SULFATE (HIKMA) APPROVAL= AP YEAR= 2008
NDA 022321 (label) INN (MORPHINE SULFATE ; NALTREXONE HYDROCHLORIDE) EMBEDA (ALPHARMA PHARMS) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 200812 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (STRIDES PHARMA INTL) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 200824 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (RISING) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 201517 (label) INN (MORPHINE SULFATE) MORPHINE SULFATE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 202348 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (SPECGX LLC) APPROVAL= AP YEAR= 2011
NDA 202515 (label) INN (MORPHINE SULFATE) MORPHINE SULFATE (HOSPIRA INC) APPROVAL= AP YEAR= 2011
NDA 201947 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (VISTAPHARM) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 078761 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2012
NDA 201574 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (PADAGIS US) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 079040 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2013
NDA 202104 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2013
NDA 204223 (label) INN (MORPHINE SULFATE) MORPHINE SULFATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2013
NDA 201011 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (SANKALP LIFECARE) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 202718 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 203518 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (TRIS PHARMA INC) APPROVAL= AP YEAR= 2015
NDA 203849 (label) INN (MORPHINE SULFATE) MORPHINE SULFATE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2015
NDA 205758 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (HIKMA) APPROVAL= AP YEAR= 2015
NDA 202309 (label) INN (MORPHINE SULFATE) MORPHINE SULFATE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 202310 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 203602 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (NOVEL LABS INC) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 206544 (label) INN (MORPHINE SULFATE) MORPHABOND ER (OHEMO LIFE) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 091357 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 200411 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (IMPAX LABS INC) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 203519 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (TRIS PHARMA INC) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 204053 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (NOSTRUM LABS INC) APPROVAL= AP YEAR= 2016 OBSOLETE
NDA 205386 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 205634 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 206420 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (RHODES PHARMS) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 206573 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (PHARM ASSOC) APPROVAL= AP YEAR= 2016
NDA 206308 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (RHODES PHARMS) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 208603 (label) INN (MORPHINE SULFATE) ARYMO ER (ZYLA) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 208809 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (HIKMA) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 205509 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (ANI PHARMS) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 204393 (pdf not found) INN (MORPHINE SULFATE) MITIGO (PIRAMAL CRITICAL) APPROVAL= AP YEAR= 2018
NDA 210610 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2019
NDA 212451 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2020
NDA 202861 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (INTL MEDICATION SYS) APPROVAL= AP YEAR= 2021
NDA 211454 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (WINDER LABS LLC) APPROVAL= AP YEAR= 2021
NDA 203158 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (ANDA REPOSITORY) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 207270 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 215584 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (INGENUS PHARMS NJ) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 211452 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (HIKMA) APPROVAL= AP YEAR= 2023
NDA 215194 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (SPECGX LLC) APPROVAL= AP YEAR= 2023
NDA 213892 (pdf not found) INN (MORPHINE SULFATE) MORPHINE SULFATE (QUAGEN) APPROVAL= AP YEAR= 2026

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL