e-Drug3D

1183

SUPROFEN

DISCONTINUED

INN
SUPROFEN

cas 40828-46-4

CLASS

MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY
ANALGESIC
CYCLOOXYGENASE INHIBITORS

ROUTE (list)

OPHTHALMIC

ATC code

M01AE07

PK parameters

VD 2.6 LITER (65 KILOGRAM)
Cl 2.96 LITER / HOUR (65 KILOGRAM)
PPB 99 PERCENT
t1/2 2.1 HOUR

Target

TARGET PROSTAGLANDIN G/H SYNTHASE 1
PROSTAGLANDIN G/H SYNTHASE 2

PDB
6OCL (CRYSTAL STRUCTURE OF LEPORINE SERUM ALBUMIN IN COMPLEX WITH SUPROFEN)

Download experimental 3D coordinates of M5A with added hydrogens

Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2

Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1

Download SDF file

2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid

Formula:
C14H12O3S

Calculated chemical properties:

MW 259.30
NB_atoms 18
XLogP 1.83
PSA 51.57
NB_HD 0
NB_HA 3
fsp3 0.14
Lipinski(0=no;1=yes) 1

FDA
NDA 019387 (pdf not found) INN (SUPROFEN) PROFENAL (ALCON) APPROVAL= AP YEAR= 1988 DISCONTINUED