e-Drug3D
1151
MICONAZOLE
INN
MICONAZOLE
cas 22916-47-8
CLASS
METABOLISM
ANTIFUNGAL (TOPICAL)
CYTOCHROME P450 14ALPHA-DEMETHYLASE INHIBITOR
INHIBITION OF ERGOSTEROL SYNTHESIS (FUNGAL CELL MEMBRANE)
ROUTE (list)
VAGINAL TOPICAL INJECTION BUCCAL
PK parameters
Cmax 36 MICROMOLAR
PPB 88 PERCENT
t1/2 24 HOUR
TARGET CYTOCHROME P450 14ALPHA-DEMETHYLASE
Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11
Formula:
C18H14Cl4N2O
Calculated chemical properties:
MW 416.11
NB_atoms 25
XLogP 6.45
PSA 20.316
NB_HD 0
NB_HA 3
fsp3 0.17
Lipinski(0=no;1=yes) 0
NB_atoms 25
XLogP 6.45
PSA 20.316
NB_HD 0
NB_HA 3
fsp3 0.17
Lipinski(0=no;1=yes) 0
FDA
NDA 017739 (pdf not found) INN (MICONAZOLE NITRATE) MONISTAT-DERM (INSIGHT PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 017450 (label) INN (MICONAZOLE NITRATE) MONISTAT 7 (MEDTECH PRODUCTS) APPROVAL= AP YEAR= 1974
NDA 017494 (pdf not found) INN (MICONAZOLE NITRATE) MONISTAT-DERM (INSIGHT PHARMS) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 018040 (pdf not found) INN (MICONAZOLE) MONISTAT (JANSSEN PHARMA) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 018520 (pdf not found) INN (MICONAZOLE NITRATE) MONISTAT 7 (MEDTECH PRODUCTS) APPROVAL= AP YEAR= 1982
NDA 018888 (pdf not found) INN (MICONAZOLE NITRATE) MONISTAT 3 (MEDTECH PRODUCTS) APPROVAL= AP YEAR= 1984
NDA 018592 (pdf not found) INN (MICONAZOLE NITRATE) MONISTAT 5 (PERSONAL PRODS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 074030 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (TEVA PHARMS) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 020288 (pdf not found) INN (MICONAZOLE NITRATE) MONISTAT 7 COMBINATION PACK (MEDTECH PRODUCTS) APPROVAL= AP YEAR= 1993
NDA 073507 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 1993
NDA 073508 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (ACTAVIS PHARMA) APPROVAL= AP YEAR= 1993
NDA 074136 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (TEVA) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 020670 (label) INN (MICONAZOLE NITRATE) MONISTAT 3 COMBINATION PACK (MEDTECH PRODUCTS) APPROVAL= AP YEAR= 1996
NDA 074164 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE 7 (ENCUBE) APPROVAL= AP YEAR= 1996
NDA 074366 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074395 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (PERRIGO) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074414 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074444 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (SUN PHARMA CANADA) APPROVAL= AP YEAR= 1997
NDA 074586 (pdf not found) INN (MICONAZOLE NITRATE) M-ZOLE 7 DUAL PACK (ACTAVIS MID ATLANTIC) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074760 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (PERRIGO) APPROVAL= AP YEAR= 1997
NDA 020827 (label) INN (MICONAZOLE NITRATE) MONISTAT 3 (MEDTECH PRODUCTS) APPROVAL= AP YEAR= 1998
NDA 020968 (label) INN (MICONAZOLE NITRATE) MONISTAT DUAL- PAK (PERSONAL PRODS) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 074926 (label) INN (MICONAZOLE NITRATE) M-ZOLE 3 COMBINATION PACK (COSETTE PHARMS NC) APPROVAL= AP YEAR= 1999
NDA 075329 (label) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE COMBINATION PACK (L PERRIGO CO) APPROVAL= AP YEAR= 1999
NDA 021261 (label) INN (MICONAZOLE NITRATE) MONISTAT 3 COMBINATION PACK PREFILLED (MEDTECH PRODUCTS) APPROVAL= AP YEAR= 2001
NDA 021308 (label) INN (MICONAZOLE NITRATE) MONISTAT 1 COMBINATION PACK (MEDTECH PRODUCTS) APPROVAL= AP YEAR= 2001
NDA 076357 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE 3 COMBINATION PACK (PERRIGO) APPROVAL= AP YEAR= 2004
NDA 076585 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE 7 COMBINATION PACK (COSETTE PHARMS NC) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076773 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE 3 (SUN PHARMA CANADA) APPROVAL= AP YEAR= 2005
NDA 021026 (label) INN (MICONAZOLE NITRATE ; WHITE PETROLATUM ; ZINC OXIDE) VUSION (MYLAN) APPROVAL= AP YEAR= 2006
NDA 022404 (label) INN (MICONAZOLE) ORAVIG (GALT PHARMS) APPROVAL= AP YEAR= 2010
NDA 091366 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (PERRIGO R AND D) APPROVAL= AP YEAR= 2010
NDA 079114 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (PERRIGO R AND D) APPROVAL= AP YEAR= 2010
NDA 017739 (pdf not found) INN (MICONAZOLE NITRATE) MONISTAT-DERM (INSIGHT PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 017450 (label) INN (MICONAZOLE NITRATE) MONISTAT 7 (MEDTECH PRODUCTS) APPROVAL= AP YEAR= 1974
NDA 017494 (pdf not found) INN (MICONAZOLE NITRATE) MONISTAT-DERM (INSIGHT PHARMS) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 018040 (pdf not found) INN (MICONAZOLE) MONISTAT (JANSSEN PHARMA) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 018520 (pdf not found) INN (MICONAZOLE NITRATE) MONISTAT 7 (MEDTECH PRODUCTS) APPROVAL= AP YEAR= 1982
NDA 018888 (pdf not found) INN (MICONAZOLE NITRATE) MONISTAT 3 (MEDTECH PRODUCTS) APPROVAL= AP YEAR= 1984
NDA 018592 (pdf not found) INN (MICONAZOLE NITRATE) MONISTAT 5 (PERSONAL PRODS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 074030 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (TEVA PHARMS) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 020288 (pdf not found) INN (MICONAZOLE NITRATE) MONISTAT 7 COMBINATION PACK (MEDTECH PRODUCTS) APPROVAL= AP YEAR= 1993
NDA 073507 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 1993
NDA 073508 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (ACTAVIS PHARMA) APPROVAL= AP YEAR= 1993
NDA 074136 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (TEVA) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 020670 (label) INN (MICONAZOLE NITRATE) MONISTAT 3 COMBINATION PACK (MEDTECH PRODUCTS) APPROVAL= AP YEAR= 1996
NDA 074164 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE 7 (ENCUBE) APPROVAL= AP YEAR= 1996
NDA 074366 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074395 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (PERRIGO) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074414 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074444 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (SUN PHARMA CANADA) APPROVAL= AP YEAR= 1997
NDA 074586 (pdf not found) INN (MICONAZOLE NITRATE) M-ZOLE 7 DUAL PACK (ACTAVIS MID ATLANTIC) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074760 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (PERRIGO) APPROVAL= AP YEAR= 1997
NDA 020827 (label) INN (MICONAZOLE NITRATE) MONISTAT 3 (MEDTECH PRODUCTS) APPROVAL= AP YEAR= 1998
NDA 020968 (label) INN (MICONAZOLE NITRATE) MONISTAT DUAL- PAK (PERSONAL PRODS) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 074926 (label) INN (MICONAZOLE NITRATE) M-ZOLE 3 COMBINATION PACK (COSETTE PHARMS NC) APPROVAL= AP YEAR= 1999
NDA 075329 (label) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE COMBINATION PACK (L PERRIGO CO) APPROVAL= AP YEAR= 1999
NDA 021261 (label) INN (MICONAZOLE NITRATE) MONISTAT 3 COMBINATION PACK PREFILLED (MEDTECH PRODUCTS) APPROVAL= AP YEAR= 2001
NDA 021308 (label) INN (MICONAZOLE NITRATE) MONISTAT 1 COMBINATION PACK (MEDTECH PRODUCTS) APPROVAL= AP YEAR= 2001
NDA 076357 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE 3 COMBINATION PACK (PERRIGO) APPROVAL= AP YEAR= 2004
NDA 076585 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE 7 COMBINATION PACK (COSETTE PHARMS NC) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076773 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE 3 (SUN PHARMA CANADA) APPROVAL= AP YEAR= 2005
NDA 021026 (label) INN (MICONAZOLE NITRATE ; WHITE PETROLATUM ; ZINC OXIDE) VUSION (MYLAN) APPROVAL= AP YEAR= 2006
NDA 022404 (label) INN (MICONAZOLE) ORAVIG (GALT PHARMS) APPROVAL= AP YEAR= 2010
NDA 091366 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (PERRIGO R AND D) APPROVAL= AP YEAR= 2010
NDA 079114 (pdf not found) INN (MICONAZOLE NITRATE) MICONAZOLE NITRATE (PERRIGO R AND D) APPROVAL= AP YEAR= 2010