e-Drug3D

1076

PAROMOMYCIN

INN
PAROMOMYCIN

cas 7542-37-2

CLASS

METABOLISM
AMINOGLYCOSIDE
ANTIBACTERIAL
ANTIAMEBIC
INTESTINAL ANTIINFECTIVES

ROUTE (list)

ORAL

ATC code

A07AA06

PK parameters

Solubility

SOLUBLE IN WATER

Target

TARGET RIBOSOMAL DECODING A-SITE BACTERIAL 16S RRNA

PDB
5BR8 (AMBIENT-TEMPERATURE CRYSTAL STRUCTURE OF 30S RIBOSOMAL SUBUNIT FROM THERMUS THERMOPHILUS IN COMPLEX WITH PAROMOMYCIN)

Ligand code = PAR (link to the list of PDB complexes)

Download experimental 3D coordinates of PAR with added hydrogens

DrugCentral

Unknown

Download SDF file

(2R,3S,4R,5R,6S)-5-amino-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol

Formula:
C23H45N5O14

Calculated chemical properties:

MW 615.64
NB_atoms 42
XLogP -8.86
PSA 334.718
NB_HD 18
NB_HA 19
fsp3 1.00
Lipinski(0=no;1=yes) 0

FDA
NDA 060522 (pdf not found) INN (PAROMOMYCIN SULFATE) HUMATIN (PARKE DAVIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 060521 (pdf not found) INN (PAROMOMYCIN SULFATE) HUMATIN (PARKEDALE) APPROVAL= AP YEAR= 1969 DISCONTINUED
NDA 062310 (pdf not found) INN (PAROMOMYCIN SULFATE) HUMATIN (KING PFIZER) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 064171 (pdf not found) INN (PAROMOMYCIN SULFATE) PAROMOMYCIN SULFATE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 065173 (pdf not found) INN (PAROMOMYCIN SULFATE) PAROMOMYCIN SULFATE (HERITAGE) APPROVAL= AP YEAR= 2007