e-Drug3D

1069

QUINUPRISTIN

INN
QUINUPRISTIN

cas 120138-50-3

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
STREPTOGRAMINS
BACTERIAL RIBOSOME (INHIBITS THE LATE PHASE OF PROTEIN SYNTHESIS)

ROUTE (list)

INJECTION INTRAVENOUS

ATC code

J01FG02

PK parameters

VD 29 LITER (65 KILOGRAM)
Cl 46.8 LITER / HOUR (65 KILOGRAM)
PPB 66 PERCENT
t1/2 0.85 HOUR

Target

TARGET RIBOSOME
STAPHYLOCOCCUS AUREUS VIRGINIAMYCIN B LYASE

PDB
2Z2P (CATALYTICALLY INACTIVE H270A VIRGINIAMYCIN B LYASE FROM STAPHYLOCOCCUS AUREUS)

Ligand code = - (link to the list of PDB complexes)

Download experimental 3D coordinates of - with added hydrogens

DrugCentral

Unknown

Download SDF file

Virginiamycin S1, 4-[4-(dimethylamino)-N-methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]methyl]-4-oxo-2-piperidinecarboxylic acid]-

Formula:
C53H67N9O10S

Calculated chemical properties:

MW 1022.23
NB_atoms 73
XLogP 2.32
PSA 197.953
NB_HD 4
NB_HA 19
fsp3 0.53
Lipinski(0=no;1=yes) 0

FDA
NDA 050747 (label) INN (QUINUPRISTIN ; DALFOPRISTIN) SYNERCID (KING PHARMS) APPROVAL= AP YEAR= 1999
NDA 050748 (label) INN (DALFOPRISTIN ; QUINUPRISTIN) SYNERCID (KING PHARMS) APPROVAL= AP YEAR= 1999 DISCONTINUED