e-Drug3D

1057

cas 88040-23-7

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
CEPHALOSPORINS

ROUTE (list)

INJECTION INTRAVENOUS

PK parameters

F 82 PERCENT (IM)
Cmax 340.7 MICROMOLAR
VD 18 LITER
Cl 7.2 LITER / HOUR
PPB 20 PERCENT
t1/2 2 HOUR

TARGET PENICILLIN-BINDING PROTEIN

PDB
5OJ0 (PENICILLIN-BINDING PROTEIN 2X (PBP2X) FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH CEFEPIME)

Ligand code = 9WT (link to the list of PDB complexes)

Download experimental 3D coordinates of 9WT with added hydrogens

MW 480.58
NB_atoms 32
XLogP -1.28
PSA 123.04
NB_HD 3
NB_HA 10
fsp3 0.53
Lipinski(0=no;1=yes) 1

FDA
NDA 050679 (label) INN (CEFEPIME HYDROCHLORIDE) MAXIPIME (HOSPIRA INC) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 065369 (pdf not found) INN (CEFEPIME HYDROCHLORIDE) CEFEPIME HYDROCHLORIDE (HOSPIRA INC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 050817 (label) INN (CEFEPIME HYDROCHLORIDE) CEFEPIME IN PLASTIC CONTAINER (BAXTER HLTHCARE) APPROVAL= AP YEAR= 2008
NDA 065441 (pdf not found) INN (CEFEPIME HYDROCHLORIDE) CEFEPIME HYDROCHLORIDE (ACS DOBFAR) APPROVAL= AP YEAR= 2008
NDA 050821 (label) INN (CEFEPIME HYDROCHLORIDE) CEFEPIME AND DEXTROSE IN DUPLEX CONTAINER (B BRAUN) APPROVAL= AP YEAR= 2010
NDA 090291 (pdf not found) INN (CEFEPIME HYDROCHLORIDE) CEFEPIME HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 202268 (pdf not found) INN (CEFEPIME HYDROCHLORIDE) CEFEPIME HYDROCHLORIDE (HOSPIRA INC) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 203704 (pdf not found) INN (CEFEPIME HYDROCHLORIDE) CEFEPIME HYDROCHLORIDE (QILU ANTIBIOTICS) APPROVAL= AP YEAR= 2016
NDA 091048 (pdf not found) INN (CEFEPIME HYDROCHLORIDE) CEFEPIME HYDROCHLORIDE (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2017
NDA 209408 (pdf not found) INN (CEFEPIME HYDROCHLORIDE) CEFEPIME HYDROCHLORIDE IN PLASTIC CONTAINER (SAMSON MEDCL) APPROVAL= AP YEAR= 2018
NDA 212721 (pdf not found) INN (CEFEPIME HYDROCHLORIDE) CEFEPIME HYDROCHLORIDE (ASTRAL) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 214402 (pdf not found) INN (CEFEPIME HYDROCHLORIDE) CEFEPIME HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2024
NDA 216165 (label) INN (CEFEPIME HYDROCHLORIDE ; ENMETAZOBACTAM) EXBLIFEP (ORCHID PHARMA) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 220787 (label) INN (CEFEPIME HYDROCHLORIDE ; ZIDEBACTAM) ZAYNICH (WOCKHARDT BIO AG) APPROVAL= AP YEAR= 2026