e-Drug3D

1054

cas 83905-01-5

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
MACROLIDES
ANTIMALARIALS

ROUTE (list)

ORAL INJECTION OPHTHALMIC

PK parameters

F 34 PERCENT
Cmax 1.33 MICROMOLAR
VD 2021 LITER (65 KILOGRAM)
Cl 37.8 LITER / HOUR
PPB 29 PERCENT
t1/2 68 HOUR

TARGET 50S RIBOSOMAL PROTEIN

PDB
5UXD (CRYSTAL STRUCTURE OF MACROLIDE 2'-PHOSPHOTRANSFERASE MPHH FROM BRACHYBACTERIUM FAECIUM IN COMPLEX WITH AZITHROMYCIN)

Ligand code = ZIT (link to the list of PDB complexes)

Download experimental 3D coordinates of ZIT with added hydrogens

MW 748.98
NB_atoms 52
XLogP 1.90
PSA 151.124
NB_HD 5
NB_HA 14
fsp3 0.97
Lipinski(0=no;1=yes) 0

FDA
NDA 050670 (label) INN (AZITHROMYCIN) ZITHROMAX (PFIZER) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 050693 (label) INN (AZITHROMYCIN) ZITHROMAX (PFIZER) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 050710 (label) INN (AZITHROMYCIN) ZITHROMAX (PFIZER) APPROVAL= AP YEAR= 1995
NDA 050711 (label) INN (AZITHROMYCIN) ZITHROMAX (PFIZER) APPROVAL= AP YEAR= 1996
NDA 050730 (label) INN (AZITHROMYCIN) ZITHROMAX (PFIZER) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 050733 (label) INN (AZITHROMYCIN) ZITHROMAX (PFIZER) APPROVAL= AP YEAR= 1997
NDA 050762 (label) INN (AZITHROMYCIN DIHYDRATE ; TROVAFLOXACIN MESYLATE) TROVAN/ZITHROMAX COMPLIANCE PAK (PFIZER) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 050784 (label) INN (AZITHROMYCIN) ZITHROMAX (PFIZER) APPROVAL= AP YEAR= 2002
NDA 050797 (label) INN (AZITHROMYCIN) ZMAX (PF PRISM CV) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 065150 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (TEVA) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 065153 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (TEVA) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 065179 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2005
NDA 065193 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (TEVA) APPROVAL= AP YEAR= 2005
NDA 065209 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (SANDOZ) APPROVAL= AP YEAR= 2005
NDA 065211 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (SANDOZ) APPROVAL= AP YEAR= 2005
NDA 065212 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (SANDOZ) APPROVAL= AP YEAR= 2005
NDA 065218 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (PLIVA) APPROVAL= AP YEAR= 2005
NDA 065223 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (PLIVA) APPROVAL= AP YEAR= 2005
NDA 065225 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (PLIVA) APPROVAL= AP YEAR= 2005
NDA 050809 (label) INN (AZITHROMYCIN) AZITHROMYCIN (TEVA PARENTERAL) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 065246 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (PLIVA) APPROVAL= AP YEAR= 2006
NDA 065297 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (SANDOZ) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 050810 (label) INN (AZITHROMYCIN) AZASITE (THEA PHARMA) APPROVAL= AP YEAR= 2007
NDA 065265 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (HIKMA) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 065360 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 065365 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (PHARMOBEDIENT) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 065366 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (EXTROVIS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 065302 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (CHARTWELL RX) APPROVAL= AP YEAR= 2008
NDA 065404 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (CHARTWELL RX) APPROVAL= AP YEAR= 2008
NDA 065405 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (CHARTWELL RX) APPROVAL= AP YEAR= 2008
NDA 065419 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (TEVA PHARMS) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 065500 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (HOSPIRA) APPROVAL= AP YEAR= 2009
NDA 065501 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (GLAND PHARMA LTD) APPROVAL= AP YEAR= 2009
NDA 065506 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (PHARMOBEDIENT) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 065511 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (HOSPIRA) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 065507 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (APOTEX CORP) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 065508 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (APOTEX CORP) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 065509 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (APOTEX CORP) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090923 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 202308 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (SANDOZ INC) APPROVAL= TA YEAR= 2014
NDA 065398 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (LUPIN) APPROVAL= AP YEAR= 2015
NDA 065399 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (LUPIN) APPROVAL= AP YEAR= 2015
NDA 065400 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (LUPIN) APPROVAL= AP YEAR= 2015
NDA 065488 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (CHARTWELL RX) APPROVAL= AP YEAR= 2015
NDA 203294 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (EUGIA PHARMA) APPROVAL= AP YEAR= 2015
NDA 202793 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (NOVEL LABS INC) APPROVAL= TA YEAR= 2016
NDA 204732 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (RISING) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 203412 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (SLATE RUN PHARMA) APPROVAL= AP YEAR= 2018
NDA 205666 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (AMNEAL) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 207531 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2018
NDA 207370 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2018
NDA 207398 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2018
NDA 207566 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (CSPC OUYI) APPROVAL= AP YEAR= 2018
NDA 208249 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (CSPC OUYI) APPROVAL= AP YEAR= 2018
NDA 209043 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (SUNSHINE) APPROVAL= AP YEAR= 2018
NDA 209044 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (SUNSHINE) APPROVAL= AP YEAR= 2018
NDA 209045 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (SUNSHINE) APPROVAL= AP YEAR= 2018
NDA 209201 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2018
NDA 209999 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (BIONPHARMA) APPROVAL= AP YEAR= 2018
NDA 211147 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2018
NDA 208250 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (CSPC OUYI) APPROVAL= AP YEAR= 2019
NDA 210000 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (BIONPHARMA) APPROVAL= AP YEAR= 2019
NDA 210001 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (BIONPHARMA) APPROVAL= AP YEAR= 2019
NDA 211521 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (TARO) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 211068 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (CARLSBAD) APPROVAL= AP YEAR= 2020
NDA 211791 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (ALEMBIC) APPROVAL= AP YEAR= 2020
NDA 211792 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (ALEMBIC) APPROVAL= AP YEAR= 2020
NDA 211793 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (ALEMBIC) APPROVAL= AP YEAR= 2020
NDA 211318 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (PHARMOBEDIENT) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 211317 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (CARLSBAD) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 215772 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (STRIDES PHARMA) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 215773 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (STRIDES PHARMA) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 213056 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 213275 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 217036 (pdf not found) INN (AZITHROMYCIN) AZITHROMYCIN (ZHEJIANG POLY PHARM) APPROVAL= AP YEAR= 2023