e-Drug3D

1053

LORACARBEF

DISCONTINUED

INN
LORACARBEF

cas 76470-66-1

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
CEPHALOSPORINS
CARBACEPHEM

ROUTE (list)

ORAL

ATC code

J01DC08

PK parameters

VD 25 LITER (65 KILOGRAM , PMID7983236)
Cl 14.4 LITER / HOUR (EQN)
PPB 35 PERCENT (PMID8507756)
t1/2 1.2 HOUR

Target

TARGET PENICILLIN-BINDING PROTEINS 1A/1B

DrugCentral

Bacterial penicillin-binding protein UNIPROT P02918 mrcA

Download SDF file

7-[(2-amino-2-phenylacetyl)amino]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Formula:
C16H16ClN3O4

Calculated chemical properties:

MW 348.76
NB_atoms 24
XLogP -0.62
PSA 103.688
NB_HD 3
NB_HA 7
fsp3 0.31
Lipinski(0=no;1=yes) 1

FDA
NDA 050667 (pdf not found) INN (LORACARBEF) LORABID (KING PHARMS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 050668 (pdf not found) INN (LORACARBEF) LORABID (KING PHARMS) APPROVAL= AP YEAR= 1991 DISCONTINUED