e-Drug3D

1051

cas 81103-11-9

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
MACROLIDES

ROUTE (list)

ORAL

PK parameters

F 50 PERCENT
Cmax 5 MICROMOLAR
VD 97.5 LITER (65 KILOGRAM)
Cl 28.5 LITER / HOUR (65 KILOGRAM)
PPB 77 PERCENT
t1/2 6 HOUR

TARGET 50S RIBOSOMAL PROTEIN

PDB
5IGW (MACROLIDE 2'-PHOSPHOTRANSFERASE TYPE II - COMPLEX WITH GDP AND CLARITHROMYCIN)

Ligand code = CTY (link to the list of PDB complexes)

Download experimental 3D coordinates of CTY with added hydrogens

MW 747.94
NB_atoms 52
XLogP 2.44
PSA 167.788
NB_HD 4
NB_HA 14
fsp3 0.95
Lipinski(0=no;1=yes) 0

FDA
NDA 050662 (label) INN (CLARITHROMYCIN) BIAXIN (ABBVIE) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 050697 (pdf not found) INN (CLARITHROMYCIN) BIAXIN XL (ABBVIE INC) APPROVAL= AP YEAR= 1993 NEWAPPLICATION DISCONTINUED
NDA 050698 (label) INN (CLARITHROMYCIN) BIAXIN (ABBVIE) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 050757 (label) INN (AMOXICILLIN ; CLARITHROMYCIN ; LANSOPRAZOLE) PREVPAC COPACKAGED (TAKEDA PHARMS USA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 050775 (label) INN (CLARITHROMYCIN) BIAXIN XL (ABBVIE) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 065145 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 2004
NDA 065174 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 065178 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (HIKMA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 065136 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (SANDOZ) APPROVAL= AP YEAR= 2005
NDA 065137 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 065144 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (SANDOZ) APPROVAL= AP YEAR= 2005
NDA 065154 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (DR REDDYS LABS SA) APPROVAL= AP YEAR= 2005
NDA 065155 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (TEVA) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 065195 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (PHARMOBEDIENT) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 065210 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (RANBAXY) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 065250 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (ANI PHARMS) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 065266 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (WOCKHARDT) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 065283 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (SANDOZ) APPROVAL= AP YEAR= 2007
NDA 065382 (label) INN (CLARITHROMYCIN) CLARITHROMYCIN (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 065384 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (CHARTWELL) APPROVAL= AP YEAR= 2007
NDA 050824 (label) INN (AMOXICILLIN ; CLARITHROMYCIN ; OMEPRAZOLE) OMECLAMOX-PAK (CUMBERLAND) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 065489 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (AUROBINDO) APPROVAL= AP YEAR= 2012
NDA 200218 (pdf not found) INN (AMOXICILLIN ; CLARITHROMYCIN ; LANSOPRAZOLE) LANSOPRAZOLE, AMOXICILLIN AND CLARITHROMYCIN COPACKAGED (ANI PHARMS) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 202710 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2013
NDA 202588 (pdf not found) INN (AMOXICILLIN ; CLARITHROMYCIN ; LANSOPRAZOLE) LANSOPRAZOLE, AMOXICILLIN AND CLARITHROMYCIN COPACKAGED (SANDOZ) APPROVAL= AP YEAR= 2014
NDA 203584 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (HEC PHARM) APPROVAL= AP YEAR= 2015
NDA 202532 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (LUPIN) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 203243 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (MPP PHARMA) APPROVAL= AP YEAR= 2016
NDA 206006 (pdf not found) INN (AMOXICILLIN ; CLARITHROMYCIN ; LANSOPRAZOLE) LANSOPRAZOLE, AMOXICILLIN AND CLARITHROMYCIN COPACKAGED (RISING) APPROVAL= AP YEAR= 2016
NDA 208987 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (SUNSHINE) APPROVAL= AP YEAR= 2018
NDA 206714 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (JUBILANT CADISTA) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 210459 (pdf not found) INN (CLARITHROMYCIN) CLARITHROMYCIN (ALEMBIC) APPROVAL= AP YEAR= 2022
NDA 215152 (label) INN (AMOXICILLIN ; CLARITHROMYCIN ; VONOPRAZAN FUMARATE) VOQUEZNA TRIPLE PAK (PHATHOM) APPROVAL= AP YEAR= 2022