e-Drug3D

1050

IDARUBICIN

INN
IDARUBICIN

cas 58957-92-9

CLASS

ANTINEOPLASTIC
ANTIBIOTICS
CYTOTOXIC
ANTHRACYCLINES
ANTILEUKEMIC DRUG

ROUTE (list)

INTRAVENOUS

ATC code

L01DB06

PK parameters

VD 2470 LITER (65 KILOGRAM)
Cl 93 LITER / HOUR (65 KILOGRAM)
PPB 97 PERCENT
t1/2 22 HOUR

Target

TARGET DNA TOPOISOMERASE 2-ALPHA

PDB
4LB2 (X-RAY STUDY OF HUMAN SERUM ALBUMIN COMPLEXED WITH IDARUBICIN)

Ligand code = DM5 (link to the list of PDB complexes)

Download experimental 3D coordinates of DM5 with added hydrogens

DrugCentral

DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A

Download SDF file

(7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione

Formula:
C26H27NO9

Calculated chemical properties:

MW 497.49
NB_atoms 36
XLogP 1.02
PSA 161.075
NB_HD 6
NB_HA 10
fsp3 0.42
Lipinski(0=no;1=yes) 0

FDA
NDA 050661 (label) INN (IDARUBICIN HYDROCHLORIDE) IDAMYCIN (PFIZER) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 050734 (label) INN (IDARUBICIN HYDROCHLORIDE) IDAMYCIN PFS (PFIZER) APPROVAL= AP YEAR= 1997
NDA 065036 (pdf not found) INN (IDARUBICIN HYDROCHLORIDE) IDARUBICIN HYDROCHLORIDE (MEITHEAL) APPROVAL= AP YEAR= 2002
NDA 065037 (pdf not found) INN (IDARUBICIN HYDROCHLORIDE) IDARUBICIN HYDROCHLORIDE (TEVA PARENTERAL) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 065275 (pdf not found) INN (IDARUBICIN HYDROCHLORIDE) IDARUBICIN HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2006
NDA 065288 (pdf not found) INN (IDARUBICIN HYDROCHLORIDE) IDARUBICIN HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2007
NDA 065440 (pdf not found) INN (IDARUBICIN HYDROCHLORIDE) IDARUBICIN HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 091293 (pdf not found) INN (IDARUBICIN HYDROCHLORIDE) IDARUBICIN HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 200144 (pdf not found) INN (IDARUBICIN HYDROCHLORIDE) IDARUBICIN HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2012 DISCONTINUED