e-Drug3D

1040

AZTREONAM

INN
AZTREONAM

cas 78110-38-0

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTI-BACTERIAL
INHIBITION OF BACTERIAL CELL WALL SYNTHESIS

ROUTE (list)

INJECTION INHALATION INTRAVENOUS

ATC code

J01DF01
J01DF51

PK parameters

VD 12.6 LITER
Cl 5.4 LITER / HOUR
PPB 60 PERCENT
t1/2 1.7 HOUR

Target

TARGET PENICILLIN-BINDING PROTEIN 3
BETA-LACTAMASE

PDB
1FR6 (BETA-LACTAMASE FROM CITROBACTER FREUNDII)

Ligand code = - (link to the list of PDB complexes)

Download experimental 3D coordinates of - with added hydrogens

DrugCentral

Peptidoglycan synthase FtsI UNIPROT P0AD68 ftsI

Penicillin-binding protein 1A UNIPROT P02918 mrcA

Download SDF file

(2S,3S)-3-[[(2E)-2-(2-azaniumyl-1,3-thiazol-4-yl)-2-(1-hydroxy-2-methyl-1-oxopropan-2-yl)oxyiminoacetyl]amino]-2-methyl-4-oxoazetidine-1-sulfonate

Formula:
C13H17N5O8S2

Calculated chemical properties:

MW 434.45
NB_atoms 28
XLogP -2.51
PSA 186.897
NB_HD 4
NB_HA 13
fsp3 0.46
Lipinski(0=no;1=yes) 0

FDA
NDA 050580 (label) INN (AZTREONAM) AZACTAM (LABS DELBERT) APPROVAL= AP YEAR= 1986
NDA 050632 (label) INN (AZTREONAM) AZACTAM IN PLASTIC CONTAINER (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 050814 (label) INN (AZTREONAM) CAYSTON (GILEAD) APPROVAL= AP YEAR= 2010
NDA 065439 (pdf not found) INN (AZTREONAM) AZTREONAM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2010
NDA 065286 (pdf not found) INN (AZTREONAM) AZTREONAM (HIKMA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 206517 (pdf not found) INN (AZTREONAM) AZTREONAM (HOSPIRA) APPROVAL= AP YEAR= 2021
NDA 217906 (label) INN (AVIBACTAM SODIUM ; AZTREONAM) EMBLAVEO (ABBVIE) APPROVAL= AP YEAR= 2025
NDA 207069 (pdf not found) INN (AZTREONAM) AZTREONAM (HIKMA) APPROVAL= AP YEAR= 2026 DISCONTINUED