e-Drug3D

1034

cas 58001-44-8

CLASS

ANTIINFECTIVES
ANTIBACTERIAL

ROUTE (list)

ORAL INJECTION

PK parameters

Cmax 12 MICROMOLAR (125 MILLIGRAM)
VD 14.3 LITER (65 KILOGRAM)
Cl 12 LITER / HOUR (65 KILOGRAM)
PPB 25 PERCENT
t1/2 1.0 HOUR

TARGET BETA-LACTAMASE

PDB
2XFS (STRUCTURAL AND MECHANISTIC STUDIES ON A CEPHALOSPORIN ESTERASE FROM THE CLAVULANIC ACID BIOSYNTHESIS PATHWAY)

Ligand code = J01 (link to the list of PDB complexes)

Download experimental 3D coordinates of J01 with added hydrogens

MW 198.15
NB_atoms 14
XLogP -2.43
PSA 91.554
NB_HD 1
NB_HA 6
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 050564 (label) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AUGMENTIN '250' (US ANTIBIOTICS) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 050575 (label) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AUGMENTIN '125' (US ANTIBIOTICS) APPROVAL= AP YEAR= 1984
NDA 050590 (label) INN (CLAVULANATE POTASSIUM ; TICARCILLIN DISODIUM) TIMENTIN (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 050597 (label) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AUGMENTIN '125' (US ANTIBIOTICS) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 062691 (pdf not found) INN (CLAVULANATE POTASSIUM ; TICARCILLIN DISODIUM) TIMENTIN (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 050658 (label) INN (CLAVULANATE POTASSIUM ; TICARCILLIN DISODIUM) TIMENTIN IN PLASTIC CONTAINER (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 050720 (label) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AUGMENTIN '875' (US ANTIBIOTICS) APPROVAL= AP YEAR= 1996
NDA 050725 (label) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AUGMENTIN '200' (US ANTIBIOTICS) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 050726 (label) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AUGMENTIN '200' (US ANTIBIOTICS) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 050755 (label) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AUGMENTIN ES-600 (US ANTIBIOTICS) APPROVAL= AP YEAR= 2001
NDA 050785 (label) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AUGMENTIN XR (US ANTIBIOTICS) APPROVAL= AP YEAR= 2002
NDA 065063 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (SANDOZ) APPROVAL= AP YEAR= 2002
NDA 065064 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (SANDOZ) APPROVAL= AP YEAR= 2002
NDA 065065 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (CHARTWELL RX) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 065066 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (SANDOZ) APPROVAL= AP YEAR= 2002
NDA 065093 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (SANDOZ INC) APPROVAL= AP YEAR= 2002
NDA 065096 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (TEVA PHARMS USA) APPROVAL= AP YEAR= 2002
NDA 065098 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (SANDOZ INC) APPROVAL= AP YEAR= 2002
NDA 065101 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (TEVA) APPROVAL= AP YEAR= 2002
NDA 065102 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 065109 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 065117 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (SANDOZ INC) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 065132 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 065161 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 065089 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (TEVA) APPROVAL= AP YEAR= 2004
NDA 065162 (label) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (TEVA) APPROVAL= AP YEAR= 2004
NDA 065189 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (SANDOZ) APPROVAL= AP YEAR= 2005
NDA 065191 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (HIKMA PHARMS) APPROVAL= AP YEAR= 2005
NDA 065205 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (TEVA) APPROVAL= AP YEAR= 2005
NDA 065207 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 065358 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (SANDOZ INC) APPROVAL= AP YEAR= 2007
NDA 065373 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (HIKMA PHARMS) APPROVAL= AP YEAR= 2007
NDA 065317 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (APOTEX INC) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 065431 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (CIPLA) APPROVAL= AP YEAR= 2008
NDA 065333 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (APOTEX INC) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090227 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (SANDOZ) APPROVAL= AP YEAR= 2010
NDA 201090 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2011
NDA 201091 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2011
NDA 091568 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2012
NDA 091569 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2012
NDA 065420 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (CIPLA) APPROVAL= AP YEAR= 2013
NDA 203824 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (HIKMA PHARMS) APPROVAL= AP YEAR= 2016
NDA 204755 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (MICRO LABS LTD INDIA) APPROVAL= AP YEAR= 2016
NDA 205707 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (MICRO LABS LTD INDIA) APPROVAL= AP YEAR= 2016
NDA 209371 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2019
NDA 205187 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (MICRO LABS LTD INDIA) APPROVAL= AP YEAR= 2021
NDA 209351 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (DEVA HOLDING AS) APPROVAL= AP YEAR= 2023
NDA 209991 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (DEVA HOLDING AS) APPROVAL= AP YEAR= 2023
NDA 209992 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (DEVA HOLDING AS) APPROVAL= AP YEAR= 2023
NDA 210374 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (DEVA HOLDING AS) APPROVAL= AP YEAR= 2023
NDA 210416 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (DEVA HOLDING AS) APPROVAL= AP YEAR= 2023
NDA 217805 (pdf not found) INN (AMOXICILLIN ; CLAVULANATE POTASSIUM) AMOXICILLIN AND CLAVULANATE POTASSIUM (MICRO LABS) APPROVAL= AP YEAR= 2023