e-Drug3D

1029

cas 55268-75-2

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
CEPHALOSPORINS

ROUTE (list)

INTRAMUSCULAR INTRAVENOUS INJECTION

PK parameters

Tmax 2.5 HOUR
Cmax 32 MICROMOLAR (1 GRAM)
VD 9.7 LITER (65 KILOGRAM)
Cl 8.6 LITER / HOUR (65 KILOGRAM)
PPB 50 PERCENT
t1/2 1.3 HOUR

TARGET PENICILLIN-BINDING PROTEINS 1A/1B

PDB
4KOV (CRYSTAL STRUCTURE OF A GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794 IN COMPLEX WITH CEFUROXIME)

Ligand code = KOV (link to the list of PDB complexes)

Download experimental 3D coordinates of KOV with added hydrogens

MW 423.39
NB_atoms 29
XLogP -1.87
PSA 153.792
NB_HD 3
NB_HA 12
fsp3 0.31
Lipinski(0=no;1=yes) 0

FDA
NDA 050558 (label) INN (CEFUROXIME SODIUM) ZINACEF (PAI HOLDINGS PHARM) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 062590 (pdf not found) INN (CEFUROXIME SODIUM) KEFUROX IN PLASTIC CONTAINER (LILLY) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 062591 (pdf not found) INN (CEFUROXIME SODIUM) KEFUROX (ACS DOBFAR) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 062592 (pdf not found) INN (CEFUROXIME SODIUM) KEFUROX (LILLY) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 050643 (label) INN (CEFUROXIME SODIUM) ZINACEF IN PLASTIC CONTAINER (PAI HOLDINGS PHARM) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 064035 (pdf not found) INN (CEFUROXIME SODIUM) CEFUROXIME SODIUM (WATSON LABS INC) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 064036 (pdf not found) INN (CEFUROXIME SODIUM) CEFUROXIME SODIUM (WATSON LABS INC) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 064124 (pdf not found) INN (CEFUROXIME SODIUM) CEFUROXIME SODIUM (ACS DOBFAR SPA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 064125 (pdf not found) INN (CEFUROXIME SODIUM) CEFUROXIME SODIUM (ACS DOBFAR SPA) APPROVAL= AP YEAR= 1997
NDA 064191 (pdf not found) INN (CEFUROXIME SODIUM) CEFUROXIME SODIUM (TEVA PHARMS) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 064192 (pdf not found) INN (CEFUROXIME SODIUM) CEFUROXIME SODIUM (TEVA PHARMS) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 065002 (pdf not found) INN (CEFUROXIME SODIUM) CEFUROXIME SODIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 050780 (label) INN (CEFUROXIME SODIUM) CEFUROXIME AND DEXTROSE IN DUPLEX CONTAINER (B BRAUN) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 065001 (pdf not found) INN (CEFUROXIME SODIUM) CEFUROXIME SODIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 065046 (pdf not found) INN (CEFUROXIME SODIUM) CEFUROXIME SODIUM (HIKMA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 065048 (pdf not found) INN (CEFUROXIME) CEFUROXIME (HIKMA) APPROVAL= AP YEAR= 2004
NDA 065483 (pdf not found) INN (CEFUROXIME SODIUM) CEFUROXIME SODIUM (HOSPIRA INC) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 065484 (pdf not found) INN (CEFUROXIME SODIUM) CEFUROXIME SODIUM (HOSPIRA INC) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 065503 (pdf not found) INN (CEFUROXIME SODIUM) CEFUROXIME SODIUM (HOSPIRA INC) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 065251 (pdf not found) INN (CEFUROXIME SODIUM) CEFUROXIME SODIUM IN PLASTIC CONTAINER (SAMSON MEDCL) APPROVAL= AP YEAR= 2009 DISCONTINUED