e-Drug3D

1018

cas 35607-66-0

CLASS

ANTIINFECTIVES
ANTIBACTERIAL
ANTIBIOTIC
CEPHALOSPORINS
INHIBITION OF CELL WALL SYNTHESIS

ROUTE (list)

INJECTION INTRAVENOUS

PK parameters

Cmax 257 MICROMOLAR (1 GRAM)
VD 11 LITER (65 KILOGRAM)
Cl 14 LITER / HOUR (65 KILOGRAM)
PPB 27 PERCENT
t1/2 0.81 HOUR

TARGET PENICILLIN-BINDING PROTEINS 1A/1B
BETA-LACTAMASE
BETA-LACTAMASE CTX-M-9A

PDB
4KOW (CRYSTAL STRUCTURE OF A GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794 IN COMPLEX WITH CEFOXITIN)

Ligand code = CFX (link to the list of PDB complexes)

Download experimental 3D coordinates of CFX with added hydrogens

MW 426.46
NB_atoms 28
XLogP -1.24
PSA 129.872
NB_HD 3
NB_HA 10
fsp3 0.38
Lipinski(0=no;1=yes) 1

FDA
NDA 050517 (label) INN (CEFOXITIN SODIUM) MEFOXIN (PHARMOBEDIENT) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 062757 (pdf not found) INN (CEFOXITIN SODIUM) MEFOXIN (PHARMOBEDIENT) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 063182 (pdf not found) INN (CEFOXITIN SODIUM) MEFOXIN IN PLASTIC CONTAINER (PHARMOBEDIENT) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 050581 (pdf not found) INN (CEFOXITIN SODIUM) MEFOXIN IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER (MERCK) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 065011 (pdf not found) INN (CEFOXITIN SODIUM) CEFOXITIN (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 065012 (pdf not found) INN (CEFOXITIN SODIUM) CEFOXITIN (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 065050 (pdf not found) INN (CEFOXITIN SODIUM) CEFOXITIN (HIKMA) APPROVAL= AP YEAR= 2000
NDA 065051 (pdf not found) INN (CEFOXITIN SODIUM) CEFOXITIN (HIKMA) APPROVAL= AP YEAR= 2000
NDA 065214 (label) INN (CEFOXITIN SODIUM) CEFOXITIN AND DEXTROSE IN DUPLEX CONTAINER (B BRAUN) APPROVAL= AP YEAR= 2006
NDA 065312 (pdf not found) INN (CEFOXITIN SODIUM) CEFOXITIN (HOSPIRA INC) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 065313 (pdf not found) INN (CEFOXITIN SODIUM) CEFOXITIN (HOSPIRA INC) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 065414 (pdf not found) INN (CEFOXITIN SODIUM) CEFOXITIN (ACS DOBFAR) APPROVAL= AP YEAR= 2009
NDA 065238 (pdf not found) INN (CEFOXITIN SODIUM) CEFOXITIN (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2010
NDA 065239 (pdf not found) INN (CEFOXITIN SODIUM) CEFOXITIN (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2010
NDA 065415 (pdf not found) INN (CEFOXITIN SODIUM) CEFOXITIN (ACS DOBFAR) APPROVAL= AP YEAR= 2010
NDA 065464 (pdf not found) INN (CEFOXITIN SODIUM) CEFOXITIN (ACS DOBFAR SPA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 065467 (pdf not found) INN (CEFOXITIN SODIUM) CEFOXITIN (ACS DOBFAR SPA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 200938 (pdf not found) INN (CEFOXITIN SODIUM) CEFOXITIN IN PLASTIC CONTAINER (SAMSON MEDCL) APPROVAL= AP YEAR= 2015